A 3D human retina model reveals a non-cell-autonomous and non-neuronal mechanism of photoreceptor loss in a lysosomal storage disorder.
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| Title: | A 3D human retina model reveals a non-cell-autonomous and non-neuronal mechanism of photoreceptor loss in a lysosomal storage disorder. |
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| Authors: | Han J; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Foley N; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Dalvi S; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Tang JAH; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Emira Dogrul F; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Chatterjee A; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Kumar LK; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Galloway CA; Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY 14642, USA., Singh AK; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Stein LM; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Subedi Y; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Kevin C Ling; Department of Biomedical Engineering, Robert B. Goergen Hall, University of Rochester, Rochester, NY 14642, USA., Heffer A; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., He X; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA., Gullapalli VK; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Central MN Retina Specialists, Sartell, MN 56377, USA., Johnson BA; Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY 14642, USA., Libby RT; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Benoit DSW; Department of Biomedical Engineering, Robert B. Goergen Hall, University of Rochester, Rochester, NY 14642, USA.; Department of Bioengineering, University of Oregon; Knight Campus, Eugene, OR 97403 USA., Cook AL; Wicking Dementia Research and Education Centre, University of Tasmania, Tasmania, 7000, Australia., Bonilha VL; Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA.; Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA., Schuchman EH; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA., Hunter JJ; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.; School of Optometry and Vision Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada., Singh R; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2026 Aug 26; Vol. 18 (864), pp. eady7616. Date of Electronic Publication: 2026 Aug 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.ady7616 |
