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A 3D human retina model reveals a non-cell-autonomous and non-neuronal mechanism of photoreceptor loss in a lysosomal storage disorder.

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Title: A 3D human retina model reveals a non-cell-autonomous and non-neuronal mechanism of photoreceptor loss in a lysosomal storage disorder.
Authors: Han J; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Foley N; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Dalvi S; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Tang JAH; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Emira Dogrul F; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Chatterjee A; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Kumar LK; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Galloway CA; Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY 14642, USA., Singh AK; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Stein LM; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Subedi Y; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Kevin C Ling; Department of Biomedical Engineering, Robert B. Goergen Hall, University of Rochester, Rochester, NY 14642, USA., Heffer A; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., He X; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA., Gullapalli VK; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Central MN Retina Specialists, Sartell, MN 56377, USA., Johnson BA; Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY 14642, USA., Libby RT; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA., Benoit DSW; Department of Biomedical Engineering, Robert B. Goergen Hall, University of Rochester, Rochester, NY 14642, USA.; Department of Bioengineering, University of Oregon; Knight Campus, Eugene, OR 97403 USA., Cook AL; Wicking Dementia Research and Education Centre, University of Tasmania, Tasmania, 7000, Australia., Bonilha VL; Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA.; Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA., Schuchman EH; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA., Hunter JJ; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.; School of Optometry and Vision Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada., Singh R; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Aug 26; Vol. 18 (864), pp. eady7616. Date of Electronic Publication: 2026 Aug 26.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: A 3D human retina model reveals a non-cell-autonomous and non-neuronal mechanism of photoreceptor loss in a lysosomal storage disorder.
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  Data: <searchLink fieldCode="AU" term="%22Han+J%22">Han J</searchLink>; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Foley+N%22">Foley N</searchLink>; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Dalvi+S%22">Dalvi S</searchLink>; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Tang+JAH%22">Tang JAH</searchLink>; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Emira+Dogrul+F%22">Emira Dogrul F</searchLink>; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Chatterjee+A%22">Chatterjee A</searchLink>; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+LK%22">Kumar LK</searchLink>; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Galloway+CA%22">Galloway CA</searchLink>; Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Singh+AK%22">Singh AK</searchLink>; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Stein+LM%22">Stein LM</searchLink>; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Subedi+Y%22">Subedi Y</searchLink>; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Kevin+C+Ling%22">Kevin C Ling</searchLink>; Department of Biomedical Engineering, Robert B. Goergen Hall, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Heffer+A%22">Heffer A</searchLink>; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22He+X%22">He X</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Gullapalli+VK%22">Gullapalli VK</searchLink>; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Central MN Retina Specialists, Sartell, MN 56377, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+BA%22">Johnson BA</searchLink>; Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Libby+RT%22">Libby RT</searchLink>; Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA.; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA.; Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Benoit+DSW%22">Benoit DSW</searchLink>; Department of Biomedical Engineering, Robert B. 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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2026 Aug 26; Vol. 18 (864), pp. eady7616. <i>Date of Electronic Publication: </i>2026 Aug 26.
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