Long-lasting extracellular matrix modifications reshape intestinal stem cell fate and promote chronic inflammation.

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Title: Long-lasting extracellular matrix modifications reshape intestinal stem cell fate and promote chronic inflammation.
Authors: Adir I; Immunology and Regenerative Biology, The Weizmann Institute of Science, Rehovot, Israel., Sochen C; Immunology and Regenerative Biology, The Weizmann Institute of Science, Rehovot, Israel., Gelb S; Immunology and Regenerative Biology, The Weizmann Institute of Science, Rehovot, Israel., Menachem AH; Immunology and Regenerative Biology, The Weizmann Institute of Science, Rehovot, Israel., Lebon S; Immunology and Regenerative Biology, The Weizmann Institute of Science, Rehovot, Israel., Toval B; Immunology and Regenerative Biology, The Weizmann Institute of Science, Rehovot, Israel., Holiar V; Immunology and Regenerative Biology, The Weizmann Institute of Science, Rehovot, Israel., Davidzohn N; Immunology and Regenerative Biology, The Weizmann Institute of Science, Rehovot, Israel., Salame TM; Mass Cytometry Unit, Life Sciences Core Facilities, The Weizmann Institute of Science, Rehovot, Israel., Rosenhek-Goldian I; Department of Chemical Research Support, The Weizmann Institute of Science, Rehovot, Israel., Savickas S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark., Sabino F; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark., Izzi V; ECM-Hypoxia Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Ungar B; Liver Disease Center, Sheba Medical Center, Ramat Gan, Israel; Faculty of Medicine, Tel-Aviv University, Tel Aviv-Yafo, Israel., Abend A; Liver Disease Center, Sheba Medical Center, Ramat Gan, Israel; Faculty of Medicine, Tel-Aviv University, Tel Aviv-Yafo, Israel., Solomonov I; Immunology and Regenerative Biology, The Weizmann Institute of Science, Rehovot, Israel., Zigmond E; Liver Disease Center, Sheba Medical Center, Ramat Gan, Israel; Faculty of Medicine, Tel-Aviv University, Tel Aviv-Yafo, Israel., Pihlajaniemi T; ECM-Hypoxia Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Auf dem Keller U; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark., Biton M; Immunology and Regenerative Biology, The Weizmann Institute of Science, Rehovot, Israel. Electronic address: moshe.biton@weizmann.ac.il., Sagi I; Immunology and Regenerative Biology, The Weizmann Institute of Science, Rehovot, Israel. Electronic address: irit.sagi@weizmann.ac.il.
Source: Immunity [Immunity] 2026 Oct 13; Vol. 59 (10), pp. 2690-2706.e7. Date of Electronic Publication: 2026 Aug 26.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4180
DOI:10.1016/j.immuni.2026.07.022