LIM and SH3 protein 1 deficiency confers resistance to cytotoxic lymphocyte-mediated lysis and immunotherapy in gastric cancer by disrupting cytoskeleton dynamics.

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Title: LIM and SH3 protein 1 deficiency confers resistance to cytotoxic lymphocyte-mediated lysis and immunotherapy in gastric cancer by disrupting cytoskeleton dynamics.
Authors: Zhang T; NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.; International Science and Technology Cooperation Base for Tumor Translational Research of Zhejiang Province, Department of Gastrointestinal Surgery, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China., Sun Y; Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China., Chen C; NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.; International Science and Technology Cooperation Base for Tumor Translational Research of Zhejiang Province, Department of Gastrointestinal Surgery, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China., Zheng J; NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China., Chang L; NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China., Xiang Y; Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China., Zhang Q; Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China., Li H; NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; International Science and Technology Cooperation Base for Tumor Translational Research of Zhejiang Province, Department of Gastrointestinal Surgery, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China., Xie W; NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China., Xu Q; Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, Zhejiang, China., Mao C; Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China., Lu M; International Science and Technology Cooperation Base for Tumor Translational Research of Zhejiang Province, Department of Gastrointestinal Surgery, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China., Cai Z; International Science and Technology Cooperation Base for Tumor Translational Research of Zhejiang Province, Department of Gastrointestinal Surgery, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China hanzheng@wmu.edu.cn wzxxy@wmu.edu.cn 13968888872@163.com caizhenzhai@wmu.edu.cn., Shen X; NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China hanzheng@wmu.edu.cn wzxxy@wmu.edu.cn 13968888872@163.com caizhenzhai@wmu.edu.cn.; International Science and Technology Cooperation Base for Tumor Translational Research of Zhejiang Province, Department of Gastrointestinal Surgery, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China., Xue X; Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China hanzheng@wmu.edu.cn wzxxy@wmu.edu.cn 13968888872@163.com caizhenzhai@wmu.edu.cn.; International Science and Technology Cooperation Base for Tumor Translational Research of Zhejiang Province, Department of Gastrointestinal Surgery, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, Zhejiang, China., Han Z; NHC Key Laboratory of Clinical Nutrition and Intervention, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Oncology, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China hanzheng@wmu.edu.cn wzxxy@wmu.edu.cn 13968888872@163.com caizhenzhai@wmu.edu.cn.; Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Zhejiang International Cooperation Base for Tumor-Associated Pathogen and Host Interaction, Institute of Molecular Virology and Immunology, Department of Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2026 Sep 02; Vol. 14 (9). Date of Electronic Publication: 2026 Sep 02.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2051-1426
DOI:10.1136/jitc-2025-014475