Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced weight gain in female mice.
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| Title: | Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced weight gain in female mice. |
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| Authors: | Li L; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.; Department of Zoology and Physiology, Wyoming Sensory Biology Center of Biomedical Research Excellence, University of Wyoming, Laramie, WY, USA., Hernandez CC; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Gimenez LE; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Xu B; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Dahir NS; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Peisley A; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Wu Z; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Chen M; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Serrato A; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Wan R; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Swati; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Birnbaum SG; Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.; Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA., Cone RD; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. rcone@umich.edu.; Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, MI, USA. rcone@umich.edu.; Department of Molecular, Cellular and Developmental Biology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI, USA. rcone@umich.edu., Liu C; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA. chen.liu@utsouthwestern.edu.; Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA. chen.liu@utsouthwestern.edu.; Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA. chen.liu@utsouthwestern.edu. |
| Source: | Nature communications [Nat Commun] 2026 Sep 03; Vol. 17 (1). Date of Electronic Publication: 2026 Sep 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-76561-w |
