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Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced weight gain in female mice.

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Title: Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced weight gain in female mice.
Authors: Li L; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.; Department of Zoology and Physiology, Wyoming Sensory Biology Center of Biomedical Research Excellence, University of Wyoming, Laramie, WY, USA., Hernandez CC; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Gimenez LE; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Xu B; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Dahir NS; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Peisley A; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Wu Z; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Chen M; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Serrato A; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Wan R; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Swati; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Birnbaum SG; Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.; Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA., Cone RD; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. rcone@umich.edu.; Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, MI, USA. rcone@umich.edu.; Department of Molecular, Cellular and Developmental Biology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI, USA. rcone@umich.edu., Liu C; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA. chen.liu@utsouthwestern.edu.; Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA. chen.liu@utsouthwestern.edu.; Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA. chen.liu@utsouthwestern.edu.
Source: Nature communications [Nat Commun] 2026 Sep 03; Vol. 17 (1). Date of Electronic Publication: 2026 Sep 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced weight gain in female mice.
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  Data: <searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.; Department of Zoology and Physiology, Wyoming Sensory Biology Center of Biomedical Research Excellence, University of Wyoming, Laramie, WY, USA.<br /><searchLink fieldCode="AU" term="%22Hernandez+CC%22">Hernandez CC</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Gimenez+LE%22">Gimenez LE</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Xu+B%22">Xu B</searchLink>; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Dahir+NS%22">Dahir NS</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Peisley+A%22">Peisley A</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Serrato+A%22">Serrato A</searchLink>; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wan+R%22">Wan R</searchLink>; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Swati%22">Swati</searchLink>; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Birnbaum+SG%22">Birnbaum SG</searchLink>; Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.; Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Cone+RD%22">Cone RD</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. rcone@umich.edu.; Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, MI, USA. rcone@umich.edu.; Department of Molecular, Cellular and Developmental Biology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI, USA. rcone@umich.edu.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; The Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA. chen.liu@utsouthwestern.edu.; Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA. chen.liu@utsouthwestern.edu.; Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA. chen.liu@utsouthwestern.edu.
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