TDP-43 dysfunction induces cryptic circular RNAs in ALS/FTD.

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Title: TDP-43 dysfunction induces cryptic circular RNAs in ALS/FTD.
Authors: Dattilo D; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.; The Francis Crick Institute, London, UK., Pellegrini F; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.; The Francis Crick Institute, London, UK., Barattucci S; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Brown AL; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Vargas JNS; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Gatt A; Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK., Morrie R; Trace Neuroscience, South San Francisco, CA 94080, USA., Miller G; Trace Neuroscience, South San Francisco, CA 94080, USA., Bachmutsky I; Trace Neuroscience, South San Francisco, CA 94080, USA., McEachin Z; Center for Neurodegenerative Disease, Emory University, Atlanta, GA, 30329, USA., Chung M; Center for Neurodegenerative Disease, Emory University, Atlanta, GA, 30329, USA., Keuss MJ; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Ryadnov E; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Zanovello M; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Mehta PR; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Mattedi F; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Barioglio M; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Kamath S; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Kargbo-Hill SE; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA., Palade J; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Kowal I; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Glass J; Departments of Neurology and Pathology, Emory University, Atlanta, GA, USA., Gearing M; Department of Pathology and Laboratory Medicine, Department of Neurology, Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA., Lee EB; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia., Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Green EM; Trace Neuroscience, South San Francisco, CA 94080, USA., Seyfried NT; Center for Neurodegenerative Disease, Emory University, Atlanta, GA, 30329, USA., Chandriani S; Trace Neuroscience, South San Francisco, CA 94080, USA., Ward M; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Fratta P; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.; The Francis Crick Institute, London, UK.
Corporate Authors: NYGC ALS Consortium
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Sep 20. Date of Electronic Publication: 2026 Sep 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.09.17.752342