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TDP-43 dysfunction induces cryptic circular RNAs in ALS/FTD.

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Title: TDP-43 dysfunction induces cryptic circular RNAs in ALS/FTD.
Authors: Dattilo D; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.; The Francis Crick Institute, London, UK., Pellegrini F; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.; The Francis Crick Institute, London, UK., Barattucci S; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Brown AL; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Vargas JNS; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Gatt A; Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK., Morrie R; Trace Neuroscience, South San Francisco, CA 94080, USA., Miller G; Trace Neuroscience, South San Francisco, CA 94080, USA., Bachmutsky I; Trace Neuroscience, South San Francisco, CA 94080, USA., McEachin Z; Center for Neurodegenerative Disease, Emory University, Atlanta, GA, 30329, USA., Chung M; Center for Neurodegenerative Disease, Emory University, Atlanta, GA, 30329, USA., Keuss MJ; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Ryadnov E; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Zanovello M; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Mehta PR; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Mattedi F; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Barioglio M; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Kamath S; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Kargbo-Hill SE; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA., Palade J; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Kowal I; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Glass J; Departments of Neurology and Pathology, Emory University, Atlanta, GA, USA., Gearing M; Department of Pathology and Laboratory Medicine, Department of Neurology, Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA., Lee EB; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia., Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Green EM; Trace Neuroscience, South San Francisco, CA 94080, USA., Seyfried NT; Center for Neurodegenerative Disease, Emory University, Atlanta, GA, 30329, USA., Chandriani S; Trace Neuroscience, South San Francisco, CA 94080, USA., Ward M; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Fratta P; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.; The Francis Crick Institute, London, UK.
Corporate Authors: NYGC ALS Consortium
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Sep 20. Date of Electronic Publication: 2026 Sep 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: TDP-43 dysfunction induces cryptic circular RNAs in ALS/FTD.
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  Data: <searchLink fieldCode="AU" term="%22Dattilo+D%22">Dattilo D</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Pellegrini+F%22">Pellegrini F</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Barattucci+S%22">Barattucci S</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Brown+AL%22">Brown AL</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Vargas+JNS%22">Vargas JNS</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Gatt+A%22">Gatt A</searchLink>; Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Morrie+R%22">Morrie R</searchLink>; Trace Neuroscience, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Miller+G%22">Miller G</searchLink>; Trace Neuroscience, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Bachmutsky+I%22">Bachmutsky I</searchLink>; Trace Neuroscience, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22McEachin+Z%22">McEachin Z</searchLink>; Center for Neurodegenerative Disease, Emory University, Atlanta, GA, 30329, USA.<br /><searchLink fieldCode="AU" term="%22Chung+M%22">Chung M</searchLink>; Center for Neurodegenerative Disease, Emory University, Atlanta, GA, 30329, USA.<br /><searchLink fieldCode="AU" term="%22Keuss+MJ%22">Keuss MJ</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Ryadnov+E%22">Ryadnov E</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Zanovello+M%22">Zanovello M</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Mehta+PR%22">Mehta PR</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Mattedi+F%22">Mattedi F</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Barioglio+M%22">Barioglio M</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Kamath+S%22">Kamath S</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Kargbo-Hill+SE%22">Kargbo-Hill SE</searchLink>; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Palade+J%22">Palade J</searchLink>; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kowal+I%22">Kowal I</searchLink>; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Glass+J%22">Glass J</searchLink>; Departments of Neurology and Pathology, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Gearing+M%22">Gearing M</searchLink>; Department of Pathology and Laboratory Medicine, Department of Neurology, Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+EB%22">Lee EB</searchLink>; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Murray+ME%22">Murray ME</searchLink>; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Dickson+DW%22">Dickson DW</searchLink>; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Green+EM%22">Green EM</searchLink>; Trace Neuroscience, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Seyfried+NT%22">Seyfried NT</searchLink>; Center for Neurodegenerative Disease, Emory University, Atlanta, GA, 30329, USA.<br /><searchLink fieldCode="AU" term="%22Chandriani+S%22">Chandriani S</searchLink>; Trace Neuroscience, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Ward+M%22">Ward M</searchLink>; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Fratta+P%22">Fratta P</searchLink>; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.; The Francis Crick Institute, London, UK.
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  Data: <searchLink fieldCode="CA" term="%22NYGC+ALS+Consortium%22">NYGC ALS Consortium</searchLink>
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