Improving optogenetic control over Gi/o-coupled receptor signaling by optimized GIRK channel expression.
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| Title: | Improving optogenetic control over G |
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| Authors: | Mücher B; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany., Garrido-Charles A; Institute for Cardiovascular Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany.; German Center for Cardiovascular Research (DZHK), Partner site Göttingen, 37077 Göttingen, Germany., Wietek J; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany., Köhler I; Developmental Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany., Grömmke M; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany., Frischmuth T; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany., Cyganek L; German Center for Cardiovascular Research (DZHK), Partner site Göttingen, 37077 Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, 37075 Göttingen, Germany.; Stem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center Göttingen, 37075 Göttingen, Germany.; Translational Neuroinflammation and Automated Microscopy, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 37075 Göttingen, Germany., Rost BR; German Center for Cardiovascular Research (DZHK), Partner site Göttingen, 37077 Göttingen, Germany.; German Center of Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany., Bruegmann T; Institute for Cardiovascular Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany.; German Center for Cardiovascular Research (DZHK), Partner site Göttingen, 37077 Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, 37075 Göttingen, Germany.; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center Göttingen, 37075 Göttingen, Germany., Schmitz D; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.; German Center of Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.; Humboldt-Universität zu Berlin, Bernstein Center for Computational Neuroscience, 10115 Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Cell and Neurobiology, 10117 Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Einstein Center for Neuroscience, 10117 Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, NeuroCure Cluster of Excellence, 10117 Berlin, Germany., Dalkara D; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 75012 Paris, France., Wahle P; Developmental Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany., Siveke I; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany.; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Medicine Essen, 45147 Essen, Germany., Herlitze S; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany. |
| Source: | Science signaling [Sci Signal] 2026 Oct 20; Vol. 19 (960), pp. eadw4374. Date of Electronic Publication: 2026 Oct 20. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1937-9145 |
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| DOI: | 10.1126/scisignal.adw4374 |
