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Improving optogenetic control over Gi/o-coupled receptor signaling by optimized GIRK channel expression.

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Title: Improving optogenetic control over Gi/o-coupled receptor signaling by optimized GIRK channel expression.
Authors: Mücher B; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany., Garrido-Charles A; Institute for Cardiovascular Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany.; German Center for Cardiovascular Research (DZHK), Partner site Göttingen, 37077 Göttingen, Germany., Wietek J; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany., Köhler I; Developmental Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany., Grömmke M; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany., Frischmuth T; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany., Cyganek L; German Center for Cardiovascular Research (DZHK), Partner site Göttingen, 37077 Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, 37075 Göttingen, Germany.; Stem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center Göttingen, 37075 Göttingen, Germany.; Translational Neuroinflammation and Automated Microscopy, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 37075 Göttingen, Germany., Rost BR; German Center for Cardiovascular Research (DZHK), Partner site Göttingen, 37077 Göttingen, Germany.; German Center of Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany., Bruegmann T; Institute for Cardiovascular Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany.; German Center for Cardiovascular Research (DZHK), Partner site Göttingen, 37077 Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, 37075 Göttingen, Germany.; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center Göttingen, 37075 Göttingen, Germany., Schmitz D; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.; German Center of Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.; Humboldt-Universität zu Berlin, Bernstein Center for Computational Neuroscience, 10115 Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Cell and Neurobiology, 10117 Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Einstein Center for Neuroscience, 10117 Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, NeuroCure Cluster of Excellence, 10117 Berlin, Germany., Dalkara D; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 75012 Paris, France., Wahle P; Developmental Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany., Siveke I; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany.; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Medicine Essen, 45147 Essen, Germany., Herlitze S; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany.
Source: Science signaling [Sci Signal] 2026 Oct 20; Vol. 19 (960), pp. eadw4374. Date of Electronic Publication: 2026 Oct 20.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Improving optogenetic control over G<subscript>i/o</subscript>-coupled receptor signaling by optimized GIRK channel expression.
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  Data: <searchLink fieldCode="AU" term="%22Mücher+B%22">Mücher B</searchLink>; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Garrido-Charles+A%22">Garrido-Charles A</searchLink>; Institute for Cardiovascular Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany.; German Center for Cardiovascular Research (DZHK), Partner site Göttingen, 37077 Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wietek+J%22">Wietek J</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Köhler+I%22">Köhler I</searchLink>; Developmental Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Grömmke+M%22">Grömmke M</searchLink>; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Frischmuth+T%22">Frischmuth T</searchLink>; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Cyganek+L%22">Cyganek L</searchLink>; German Center for Cardiovascular Research (DZHK), Partner site Göttingen, 37077 Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, 37075 Göttingen, Germany.; Stem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center Göttingen, 37075 Göttingen, Germany.; Translational Neuroinflammation and Automated Microscopy, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 37075 Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Rost+BR%22">Rost BR</searchLink>; German Center for Cardiovascular Research (DZHK), Partner site Göttingen, 37077 Göttingen, Germany.; German Center of Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Bruegmann+T%22">Bruegmann T</searchLink>; Institute for Cardiovascular Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany.; German Center for Cardiovascular Research (DZHK), Partner site Göttingen, 37077 Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, 37075 Göttingen, Germany.; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center Göttingen, 37075 Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schmitz+D%22">Schmitz D</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.; German Center of Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.; Humboldt-Universität zu Berlin, Bernstein Center for Computational Neuroscience, 10115 Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Cell and Neurobiology, 10117 Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Einstein Center for Neuroscience, 10117 Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, NeuroCure Cluster of Excellence, 10117 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Dalkara+D%22">Dalkara D</searchLink>; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 75012 Paris, France.<br /><searchLink fieldCode="AU" term="%22Wahle+P%22">Wahle P</searchLink>; Developmental Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Siveke+I%22">Siveke I</searchLink>; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany.; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Medicine Essen, 45147 Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Herlitze+S%22">Herlitze S</searchLink>; Department of Zoology and Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101465400%22">Science signaling</searchLink> [Sci Signal] 2026 Oct 20; Vol. 19 (960), pp. eadw4374. <i>Date of Electronic Publication: </i>2026 Oct 20.
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