Discontinuation of treatment with IFN-beta leads to exacerbation of experimental autoimmune encephalomyelitis in Lewis rats. Rapid reversal of the antiproliferative activity of IFN-beta and excessive expansion of autoreactive T cells as disease promoting mechanisms.

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Title: Discontinuation of treatment with IFN-beta leads to exacerbation of experimental autoimmune encephalomyelitis in Lewis rats. Rapid reversal of the antiproliferative activity of IFN-beta and excessive expansion of autoreactive T cells as disease promoting mechanisms.
Authors: van der Meide PH; Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands. meide@bprc.nl, de Labie MC, Ruuls SR, Groenestein RJ, Botman CA, Olsson T, Dijkstra CD
Source: Journal of neuroimmunology [J Neuroimmunol] 1998 Apr 01; Vol. 84 (1), pp. 14-23.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print Cited Medium: Print ISSN: 0165-5728 (Print) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:0165-5728
DOI:10.1016/s0165-5728(97)00207-5