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Serpins and Protein Kinase Inhibitors : Novel Functions, Structural Features and Molecular Mechanisms

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Title: Serpins and Protein Kinase Inhibitors : Novel Functions, Structural Features and Molecular Mechanisms
Description: Serpins, a group of proteins with similar structures, were first identified as a set of proteins able to inhibit proteases. The first members of the serpin superfamily to be extensively studied were the human plasma proteins antithrombin and antitrypsin, which play key roles in controlling blood coagulation and inflammation. Today, over 1000 serpins have been identified, including 36 human proteins, as well as molecules in plants, fungi, bacteria, archaea and certain viruses. Serpins are thus the largest and most diverse family of protease inhibitors. In contrast, a protein kinase inhibitor is an enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Protein tyrosine kinases (PTKs) play a key role in the regulation of cell proliferation, differentiation, metabolism, migration and survival. Due to their involvement in various forms of cancer, PTKs have become prominent targets for therapy. This new book gathers the latest research from around the globe in this dynamic field.
Authors: Markovski, Sava, Georgiev, Bojidor
Resource Type: eBook.
Subjects: Serine proteinases--Inhibitors, Serpins--Physiological effect, Protein kinases--Physiological effect
Categories: SCIENCE / Life Sciences / Biochemistry
Database: eBook Collection (EBSCOhost)
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  – Type: ebook-pdf
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  Availability: 0
Header DbId: nlebk
DbLabel: eBook Collection (EBSCOhost)
An: 349621
RelevancyScore: 1031
AccessLevel: 6
PubType: eBook
PubTypeId: ebook
PreciseRelevancyScore: 1031.17456054688
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Serpins and Protein Kinase Inhibitors : Novel Functions, Structural Features and Molecular Mechanisms
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Serpins, a group of proteins with similar structures, were first identified as a set of proteins able to inhibit proteases. The first members of the serpin superfamily to be extensively studied were the human plasma proteins antithrombin and antitrypsin, which play key roles in controlling blood coagulation and inflammation. Today, over 1000 serpins have been identified, including 36 human proteins, as well as molecules in plants, fungi, bacteria, archaea and certain viruses. Serpins are thus the largest and most diverse family of protease inhibitors. In contrast, a protein kinase inhibitor is an enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Protein tyrosine kinases (PTKs) play a key role in the regulation of cell proliferation, differentiation, metabolism, migration and survival. Due to their involvement in various forms of cancer, PTKs have become prominent targets for therapy. This new book gathers the latest research from around the globe in this dynamic field.
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  Data: <searchLink fieldCode="AR" term="%22Markovski%2C+Sava%22">Markovski, Sava</searchLink><br /><searchLink fieldCode="AR" term="%22Georgiev%2C+Bojidor%22">Georgiev, Bojidor</searchLink>
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  Data: eBook.
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  Data: <searchLink fieldCode="DE" term="%22Serine+proteinases--Inhibitors%22">Serine proteinases--Inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Serpins--Physiological+effect%22">Serpins--Physiological effect</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+kinases--Physiological+effect%22">Protein kinases--Physiological effect</searchLink>
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RecordInfo BibRecord:
  BibEntity:
    Classifications:
      – Code: 572.633
        Scheme: ddc
        Type: prePub
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Serine proteinases--Inhibitors
        Type: general
      – SubjectFull: Serpins--Physiological effect
        Type: general
      – SubjectFull: Protein kinases--Physiological effect
        Type: general
    Titles:
      – TitleFull: Serpins and Protein Kinase Inhibitors : Novel Functions, Structural Features and Molecular Mechanisms
        Type: main
  BibRelationships:
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      – PersonEntity:
          Name:
            NameFull: Markovski, Sava
      – PersonEntity:
          Name:
            NameFull: Georgiev, Bojidor
      – PersonEntity:
          Name:
            NameFull: Markovski, Sava
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            NameFull: Georgiev, Bojidor
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          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2010
            – D: 04
              M: 02
              Type: profile
              Y: 2014
          Identifiers:
            – Type: isbn-print
              Value: 9781607411871
            – Type: isbn-electronic
              Value: 9781612093505
          Titles:
            – TitleFull: Serpins and Protein Kinase Inhibitors : Novel Functions, Structural Features and Molecular Mechanisms
              Type: main
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