Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

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Bibliographic Details
Title:	Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.
Authors:	Tchasovnikarova, Iva A., Timms, Richard T., Matheson, Nicholas J., Wals, Kim, Antrobus, Robin, Göttgens, Berthold, Dougan, Gordon, Dawson, Mark A., Lehner, Paul J.
Source:	Science (pre-March 2025). 6/26/2015, Vol. 348 Issue 6242, p1481-1485. 5p.
Subjects:	Proteins, Gene silencing, Epigenetics, Position effect (Genetics), Human genetics
Abstract:	The article looks at the protein complex known as the human silencing hub (HUSH) complex, which is made up of the proteins TASOR, MPP8, and periphilin. According to the authors, epigenetic silencing by this complex mediates position-effect variegation in human cells. Details on the relationship between the HUSH complex and the histone mark H3K9me3 are presented.
Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	The article looks at the protein complex known as the human silencing hub (HUSH) complex, which is made up of the proteins TASOR, MPP8, and periphilin. According to the authors, epigenetic silencing by this complex mediates position-effect variegation in human cells. Details on the relationship between the HUSH complex and the histone mark H3K9me3 are presented.
ISSN:	00368075
DOI:	10.1126/science.aaa7227