The Framingham cardiovascular risk score in multiple sclerosis.
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| Title: | The Framingham cardiovascular risk score in multiple sclerosis. |
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| Authors: | Moccia, M., Lanzillo, R., Palladino, R., Maniscalco, G. T., De Rosa, A., Russo, C., Massarelli, M., Carotenuto, A., Postiglione, E., Caporale, O., Triassi, M., Brescia Morra, V. |
| Source: | European Journal of Neurology. Aug2015, Vol. 22 Issue 8, p1176-1183. 8p. 2 Charts, 2 Graphs. |
| Subjects: | Multiple sclerosis diagnosis, Multiple sclerosis treatment, Patients, Cardiovascular diseases, Cardiovascular diseases risk factors, Neurology |
| Abstract: | Background and purpose Cardiovascular risk factors can increase the risk of multiple sclerosis ( MS) and modify its course. However, such factors possibly interact, determining a global cardiovascular risk. Our aim was to compare the global cardiovascular risk of subjects with and without MS with the simplified 10-year Framingham General Cardiovascular Disease Risk Score ( FR) and to evaluate its importance on MS-related outcomes. Methods Age, gender, smoking status, body mass index, systolic blood pressure, type II diabetes and use of antihypertensive medications were recorded in subjects with and without MS to estimate the FR, an individualized percentage risk score estimating the 10-year likelihood of cardiovascular events. Results In total, 265 MS subjects were identified with 530 matched controls. A t test showed similar FR in cases and controls ( P = 0.212). Secondary progressive MS presented significantly higher FR compared to relapsing−remitting MS ( P < 0.001). Linear regression analysis showed a direct relationship between FR and Expanded Disability Status Scale ( P < 0.001) and MS Severity Scale ( P < 0.001). Conclusion The FR, evaluating the global cardiovascular health by the interaction amongst different risk factors, relates to MS disability, severity and course. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Background and purpose Cardiovascular risk factors can increase the risk of multiple sclerosis ( MS) and modify its course. However, such factors possibly interact, determining a global cardiovascular risk. Our aim was to compare the global cardiovascular risk of subjects with and without MS with the simplified 10-year Framingham General Cardiovascular Disease Risk Score ( FR) and to evaluate its importance on MS-related outcomes. Methods Age, gender, smoking status, body mass index, systolic blood pressure, type II diabetes and use of antihypertensive medications were recorded in subjects with and without MS to estimate the FR, an individualized percentage risk score estimating the 10-year likelihood of cardiovascular events. Results In total, 265 MS subjects were identified with 530 matched controls. A t test showed similar FR in cases and controls ( P = 0.212). Secondary progressive MS presented significantly higher FR compared to relapsing−remitting MS ( P < 0.001). Linear regression analysis showed a direct relationship between FR and Expanded Disability Status Scale ( P < 0.001) and MS Severity Scale ( P < 0.001). Conclusion The FR, evaluating the global cardiovascular health by the interaction amongst different risk factors, relates to MS disability, severity and course. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 13515101 |
| DOI: | 10.1111/ene.12720 |
