Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.

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Bibliographic Details
Title:	Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.
Authors:	Meijer DH (AUTHOR), Kane MF (AUTHOR), Mehta S (AUTHOR), Liu H (AUTHOR), Harrington E (AUTHOR), Taylor CM (AUTHOR), Stiles CD (AUTHOR), Rowitch DH (AUTHOR), Meijer, Dimphna H (AUTHOR), Kane, Michael F (AUTHOR), Mehta, Shwetal (AUTHOR), Liu, Hongye (AUTHOR), Harrington, Emily (AUTHOR), Taylor, Christopher M (AUTHOR), Stiles, Charles D (AUTHOR), Rowitch, David H (AUTHOR)
Source:	Nature Reviews Neuroscience. Nov2012, Vol. 13 Issue 11, p819-831. 13p.
Abstract:	The basic helix-loop-helix transcription factors oligodendrocyte transcription factor 1 (OLIG1) and OLIG2 are structurally similar and, to a first approximation, coordinately expressed in the developing CNS and postnatal brain. Despite these similarities, it was apparent from early on after their discovery that OLIG1 and OLIG2 have non-overlapping developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes. Here, we summarize more recent insights into the separate roles of these transcription factors in the postnatal brain during repair processes and in neurological disease states, including multiple sclerosis and malignant glioma. We discuss how the unique functions of OLIG1 and OLIG2 may reflect their distinct genetic targets, co-regulator proteins and/or post-translational modifications. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	The basic helix-loop-helix transcription factors oligodendrocyte transcription factor 1 (OLIG1) and OLIG2 are structurally similar and, to a first approximation, coordinately expressed in the developing CNS and postnatal brain. Despite these similarities, it was apparent from early on after their discovery that OLIG1 and OLIG2 have non-overlapping developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes. Here, we summarize more recent insights into the separate roles of these transcription factors in the postnatal brain during repair processes and in neurological disease states, including multiple sclerosis and malignant glioma. We discuss how the unique functions of OLIG1 and OLIG2 may reflect their distinct genetic targets, co-regulator proteins and/or post-translational modifications. [ABSTRACT FROM AUTHOR]
ISSN:	1471003X
DOI:	10.1038/nrn3386