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Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.

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Title: Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.
Authors: Meijer DH (AUTHOR), Kane MF (AUTHOR), Mehta S (AUTHOR), Liu H (AUTHOR), Harrington E (AUTHOR), Taylor CM (AUTHOR), Stiles CD (AUTHOR), Rowitch DH (AUTHOR), Meijer, Dimphna H (AUTHOR), Kane, Michael F (AUTHOR), Mehta, Shwetal (AUTHOR), Liu, Hongye (AUTHOR), Harrington, Emily (AUTHOR), Taylor, Christopher M (AUTHOR), Stiles, Charles D (AUTHOR), Rowitch, David H (AUTHOR)
Source: Nature Reviews Neuroscience. Nov2012, Vol. 13 Issue 11, p819-831. 13p.
Abstract: The basic helix-loop-helix transcription factors oligodendrocyte transcription factor 1 (OLIG1) and OLIG2 are structurally similar and, to a first approximation, coordinately expressed in the developing CNS and postnatal brain. Despite these similarities, it was apparent from early on after their discovery that OLIG1 and OLIG2 have non-overlapping developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes. Here, we summarize more recent insights into the separate roles of these transcription factors in the postnatal brain during repair processes and in neurological disease states, including multiple sclerosis and malignant glioma. We discuss how the unique functions of OLIG1 and OLIG2 may reflect their distinct genetic targets, co-regulator proteins and/or post-translational modifications. [ABSTRACT FROM AUTHOR]
Copyright of Nature Reviews Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.
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  Data: <searchLink fieldCode="AR" term="%22Meijer+DH%22">Meijer DH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kane+MF%22">Kane MF</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mehta+S%22">Mehta S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu+H%22">Liu H</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Harrington+E%22">Harrington E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taylor+CM%22">Taylor CM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stiles+CD%22">Stiles CD</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rowitch+DH%22">Rowitch DH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meijer%2C+Dimphna+H%22">Meijer, Dimphna H</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kane%2C+Michael+F%22">Kane, Michael F</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mehta%2C+Shwetal%22">Mehta, Shwetal</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Hongye%22">Liu, Hongye</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Harrington%2C+Emily%22">Harrington, Emily</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taylor%2C+Christopher+M%22">Taylor, Christopher M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stiles%2C+Charles+D%22">Stiles, Charles D</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rowitch%2C+David+H%22">Rowitch, David H</searchLink> (AUTHOR)
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  Data: The basic helix-loop-helix transcription factors oligodendrocyte transcription factor 1 (OLIG1) and OLIG2 are structurally similar and, to a first approximation, coordinately expressed in the developing CNS and postnatal brain. Despite these similarities, it was apparent from early on after their discovery that OLIG1 and OLIG2 have non-overlapping developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes. Here, we summarize more recent insights into the separate roles of these transcription factors in the postnatal brain during repair processes and in neurological disease states, including multiple sclerosis and malignant glioma. We discuss how the unique functions of OLIG1 and OLIG2 may reflect their distinct genetic targets, co-regulator proteins and/or post-translational modifications. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature Reviews Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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