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Enduring efficacy of Botulinum toxin type A injection for refractory anterior knee pain.

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Title: Enduring efficacy of Botulinum toxin type A injection for refractory anterior knee pain.
Authors: Silbert, Benjamin I. (AUTHOR), Singer, Barbara J. (AUTHOR), Silbert, Peter L. (AUTHOR), Gibbons, James T. (AUTHOR), Singer, Kevin P. (AUTHOR)
Source: Disability & Rehabilitation. Jan2012, Vol. 34 Issue 1, p62-68. 7p.
Abstract: Purpose: To examine long-term outcomes of Botulinum toxin type A (BoNT-A) injection to vastus lateralis (VL) for refractory anterior knee pain (AKP). Methods: Two cohorts (private clinic referrals and previous research participants) injected with BoNT-A for AKP by one neurologist were surveyed retrospectively. Primary outcomes were self-reported benefit, duration of symptom relief, and knee surgery post-injection. Secondary outcomes were changes in utilization of medication/physiotherapy treatment, AKP symptoms and activity limitation. Results: Overall, average symptom duration was 76 months (SD 98). Responses were available from 46 of 53 private patients. Thirty-eight reported benefit from injection, which was ongoing in 29. Average benefit was 25 months (SD 21). Nine individuals reported symptom recurrence after an average of 14 months (SD 21). Ten had knee surgery post-injection; six of whom had not benefitted from BoNT-A injection. Nineteen of 23 previous research participants were contactable. Initially, all responded favorably to injection. Symptomatic benefit, with an average duration of 44 months (SD 20), persisted in 15. Two subjects proceeded to surgical intervention. Conclusions: A single BoNT-A treatment to VL led initially to improved function and relief of knee-related symptoms in 57 of 65 individuals. Improvements were sustained at follow-up, with an average benefit of 34 months (SD 25) post-injection, in 44 of 57 cases. [ABSTRACT FROM AUTHOR]
Copyright of Disability & Rehabilitation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Enduring efficacy of Botulinum toxin type A injection for refractory anterior knee pain.
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  Data: <searchLink fieldCode="AR" term="%22Silbert%2C+Benjamin+I%2E%22">Silbert, Benjamin I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Singer%2C+Barbara+J%2E%22">Singer, Barbara J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Silbert%2C+Peter+L%2E%22">Silbert, Peter L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gibbons%2C+James+T%2E%22">Gibbons, James T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Singer%2C+Kevin+P%2E%22">Singer, Kevin P.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Disability+%26+Rehabilitation%22">Disability & Rehabilitation</searchLink>. Jan2012, Vol. 34 Issue 1, p62-68. 7p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To examine long-term outcomes of Botulinum toxin type A (BoNT-A) injection to vastus lateralis (VL) for refractory anterior knee pain (AKP). Methods: Two cohorts (private clinic referrals and previous research participants) injected with BoNT-A for AKP by one neurologist were surveyed retrospectively. Primary outcomes were self-reported benefit, duration of symptom relief, and knee surgery post-injection. Secondary outcomes were changes in utilization of medication/physiotherapy treatment, AKP symptoms and activity limitation. Results: Overall, average symptom duration was 76 months (SD 98). Responses were available from 46 of 53 private patients. Thirty-eight reported benefit from injection, which was ongoing in 29. Average benefit was 25 months (SD 21). Nine individuals reported symptom recurrence after an average of 14 months (SD 21). Ten had knee surgery post-injection; six of whom had not benefitted from BoNT-A injection. Nineteen of 23 previous research participants were contactable. Initially, all responded favorably to injection. Symptomatic benefit, with an average duration of 44 months (SD 20), persisted in 15. Two subjects proceeded to surgical intervention. Conclusions: A single BoNT-A treatment to VL led initially to improved function and relief of knee-related symptoms in 57 of 65 individuals. Improvements were sustained at follow-up, with an average benefit of 34 months (SD 25) post-injection, in 44 of 57 cases. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Disability & Rehabilitation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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