Immunocytological test to detect adult carriers of (--SEA/) deletional alpha-thalassaemia.
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| Title: | Immunocytological test to detect adult carriers of (--SEA/) deletional alpha-thalassaemia. |
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| Authors: | Tang, Wozhan, Luo, Hong-Yuan, Eng, Barry, Waye, John S, Chui, David H K, Tang, W (AUTHOR), Luo, H Y (AUTHOR), Eng, B (AUTHOR), Waye, J S (AUTHOR), Chui, D H (AUTHOR) |
| Source: | Lancet. 11/6/1993, Vol. 342 Issue 8880, p1145-1147. 3p. |
| Abstract: | The gene frequency for (--SEA/) deletional alpha-thalassaemia is high in Southeast Asian populations. We report a simple immunocytological test that is highly sensitive and specific for the detection of adult carriers of the (--SEA/) deletion. We prospectively studied 206 consecutive adult blood samples. All 41 with the (--SEA/) deletion had a positive test; all but 1 of the 165 non-carriers were negative. This test, whose major requirement is a fluorescence microscope, should be useful to identify couples at risk of conceiving fetuses with homozygous alpha-thalassaemia. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | The gene frequency for (--SEA/) deletional alpha-thalassaemia is high in Southeast Asian populations. We report a simple immunocytological test that is highly sensitive and specific for the detection of adult carriers of the (--SEA/) deletion. We prospectively studied 206 consecutive adult blood samples. All 41 with the (--SEA/) deletion had a positive test; all but 1 of the 165 non-carriers were negative. This test, whose major requirement is a fluorescence microscope, should be useful to identify couples at risk of conceiving fetuses with homozygous alpha-thalassaemia. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 01406736 |
| DOI: | 10.1016/0140-6736(93)92125-d |
