Alternatives to HIV-1 RNA concentration and CD4 count to predict mortality in HIV-1-infected children in resource-poor settings.
Saved in:
| Title: | Alternatives to HIV-1 RNA concentration and CD4 count to predict mortality in HIV-1-infected children in resource-poor settings. |
|---|---|
| Authors: | Mofenson LM (AUTHOR), Harris DR (AUTHOR), Moye J (AUTHOR), Bethel J (AUTHOR), Korelitz J (AUTHOR), Read JS (AUTHOR), Nugent R (AUTHOR), Meyer W (AUTHOR), NICHD IVIG Clinical Trial Study Group (CORPORATE AUTHOR), Mofenson, L M (AUTHOR), Harris, D R (AUTHOR), Moye, J (AUTHOR), Bethel, J (AUTHOR), Korelitz, J (AUTHOR), Read, J S (AUTHOR), Nugent, R (AUTHOR), Meyer, W (AUTHOR) |
| Source: | Lancet. 11/15/2003, Vol. 362 Issue 9396, p1625-1627. 3p. |
| Abstract: | Cheaper, simpler alternatives to CD4 lymphocyte count and HIV-1 RNA detection for assessing the prognosis of HIV-1 infection are needed for resource-poor settings. However, little is known about the predictive value of alternative assays, in particular in children. We assessed the prognostic value of total lymphocyte count, immune complex-dissociated p24 antigen, white blood cell count, packed-cell volume (haematocrit), and serum albumin for mortality in 376 HIV-1-infected, mainly African-American or Hispanic children enrolled during March, 1988 to January, 1991. In a Cox proportional hazards model, including all assay-alternatives to CD4 and RNA, total lymphocyte count (p<0.0001) and serum albumin (p=0.0107) independently predicted mortality. Further assessment of these markers is warranted in resource-poor settings. [ABSTRACT FROM AUTHOR] |
| Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| Abstract: | Cheaper, simpler alternatives to CD4 lymphocyte count and HIV-1 RNA detection for assessing the prognosis of HIV-1 infection are needed for resource-poor settings. However, little is known about the predictive value of alternative assays, in particular in children. We assessed the prognostic value of total lymphocyte count, immune complex-dissociated p24 antigen, white blood cell count, packed-cell volume (haematocrit), and serum albumin for mortality in 376 HIV-1-infected, mainly African-American or Hispanic children enrolled during March, 1988 to January, 1991. In a Cox proportional hazards model, including all assay-alternatives to CD4 and RNA, total lymphocyte count (p<0.0001) and serum albumin (p=0.0107) independently predicted mortality. Further assessment of these markers is warranted in resource-poor settings. [ABSTRACT FROM AUTHOR] |
|---|---|
| ISSN: | 01406736 |
| DOI: | 10.1016/s0140-6736(03)14825-8 |
