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Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial.

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Title: Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial.
Authors: Dalziel SR (AUTHOR), Liang A (AUTHOR), Parag V (AUTHOR), Rodgers A (AUTHOR), Harding JE (AUTHOR)
Source: Pediatrics. 2004 Sep Supplement, Vol. 114 Issue 3, pe373-7. 1p.
Abstract: OBJECTIVE: To determine whether prenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome (RDS) alters blood pressure in childhood. DESIGN: Prospective follow-up study of a randomized, double-blind, placebo-controlled trial. SETTING: National Women's Hospital (Auckland, New Zealand). PARTICIPANTS: Two hundred twenty-three 6-year-old children of mothers who presented with unplanned premature labor and took part in a randomized, controlled trial of prenatal betamethasone therapy for the prevention of neonatal RDS. INTERVENTION: Mothers received 2 doses of betamethasone (12 mg) or placebo, administered through intramuscular injection, 24 hours apart. MAIN OUTCOME MEASURES: Systolic and diastolic blood pressure at 6 years of age. RESULTS: Children exposed prenatally to betamethasone (n = 121) did not differ in systolic or diastolic blood pressure from children exposed to placebo (n = 102) (mean difference: systolic: -1.6 mm Hg; 95% confidence interval: -4.1 to 0.8 mm Hg; diastolic: -0.3 mm Hg; 95% confidence interval: -2.5 to 1.8 mm Hg). CONCLUSION: Prenatal exposure to betamethasone for prevention of neonatal RDS does not alter blood pressure at 6 years of age. [ABSTRACT FROM AUTHOR]
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Database: Psychology and Behavioral Sciences Collection
Description
Abstract:OBJECTIVE: To determine whether prenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome (RDS) alters blood pressure in childhood. DESIGN: Prospective follow-up study of a randomized, double-blind, placebo-controlled trial. SETTING: National Women's Hospital (Auckland, New Zealand). PARTICIPANTS: Two hundred twenty-three 6-year-old children of mothers who presented with unplanned premature labor and took part in a randomized, controlled trial of prenatal betamethasone therapy for the prevention of neonatal RDS. INTERVENTION: Mothers received 2 doses of betamethasone (12 mg) or placebo, administered through intramuscular injection, 24 hours apart. MAIN OUTCOME MEASURES: Systolic and diastolic blood pressure at 6 years of age. RESULTS: Children exposed prenatally to betamethasone (n = 121) did not differ in systolic or diastolic blood pressure from children exposed to placebo (n = 102) (mean difference: systolic: -1.6 mm Hg; 95% confidence interval: -4.1 to 0.8 mm Hg; diastolic: -0.3 mm Hg; 95% confidence interval: -2.5 to 1.8 mm Hg). CONCLUSION: Prenatal exposure to betamethasone for prevention of neonatal RDS does not alter blood pressure at 6 years of age. [ABSTRACT FROM AUTHOR]
ISSN:00314005
DOI:10.1542/peds.2004-0196