Bibliographic Details
| Title: |
Immune mediators in the brain and peripheral tissues in autism spectrum disorder. |
| Authors: |
Estes, Myka L., McAllister, A. Kimberley |
| Source: |
Nature Reviews Neuroscience. Aug2015, Vol. 16 Issue 8, p469-486. 18p. 3 Diagrams, 1 Chart. |
| Subjects: |
Autism spectrum disorders, Brain, Cytokines, Pervasive child development disorders, Central nervous system |
| Abstract: |
Increasing evidence points to a central role for immune dysregulation in autism spectrum disorder (ASD). Several ASD risk genes encode components of the immune system and many maternal immune system-related risk factors - including autoimmunity, infection and fetal reactive antibodies - are associated with ASD. In addition, there is evidence of ongoing immune dysregulation in individuals with ASD and in animal models of this disorder. Recently, several molecular signalling pathways - including pathways downstream of cytokines, the receptor MET, major histocompatibility complex class I molecules, microglia and complement factors - have been identified that link immune activation to ASD phenotypes. Together, these findings indicate that the immune system is a point of convergence for multiple ASD-related genetic and environmental risk factors. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
