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Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples.

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Title: Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples.
Authors: Korem, Tal, Zeevi, David, Suez, Jotham, Weinberger, Adina, Avnit-Sagi, Tali, Pompan-Lotan, Maya, Matot, Elad, Jona, Ghil, Harmelin, Alon, Cohen, Nadav, Sirota-Madi, Alexandra, Thaiss, Christoph A., Pevsner-Fischer, Meirav, Sorek, Rotem, Xavier, Ramnik J., Elinav, Eran, Segal, Eran
Source: Science (pre-March 2025). 9/4/2015, Vol. 349 Issue 6252, p1101-1106. 6p.
Subjects: Microbiota, Metagenomics, Bacterial growth, Bacterial reproduction, Gut microbiota, Inflammatory bowel diseases, Type 2 diabetes
Abstract: Metagenomic sequencing increased our understanding of the role of the microbiome in health and disease, yet it only provides a snapshot of a highly dynamic ecosystem. Here, we show that the pattern of metagenomic sequencing read coverage for different microbial genomes contains a single trough and a single peak, the latter coinciding with the bacterial origin of replication. Furthermore, the ratio of sequencing coverage between the peak and trough provides a quantitative measure of a species' growth rate. We demonstrate this in vitro and in vivo, under different growth conditions, and in complex bacterial communities. For several bacterial species, peak-to-trough coverage ratios, but not relative abundances, correlated with the manifestation of inflammatory bowel disease and type II diabetes. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples.
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  Data: <searchLink fieldCode="AR" term="%22Korem%2C+Tal%22">Korem, Tal</searchLink><br /><searchLink fieldCode="AR" term="%22Zeevi%2C+David%22">Zeevi, David</searchLink><br /><searchLink fieldCode="AR" term="%22Suez%2C+Jotham%22">Suez, Jotham</searchLink><br /><searchLink fieldCode="AR" term="%22Weinberger%2C+Adina%22">Weinberger, Adina</searchLink><br /><searchLink fieldCode="AR" term="%22Avnit-Sagi%2C+Tali%22">Avnit-Sagi, Tali</searchLink><br /><searchLink fieldCode="AR" term="%22Pompan-Lotan%2C+Maya%22">Pompan-Lotan, Maya</searchLink><br /><searchLink fieldCode="AR" term="%22Matot%2C+Elad%22">Matot, Elad</searchLink><br /><searchLink fieldCode="AR" term="%22Jona%2C+Ghil%22">Jona, Ghil</searchLink><br /><searchLink fieldCode="AR" term="%22Harmelin%2C+Alon%22">Harmelin, Alon</searchLink><br /><searchLink fieldCode="AR" term="%22Cohen%2C+Nadav%22">Cohen, Nadav</searchLink><br /><searchLink fieldCode="AR" term="%22Sirota-Madi%2C+Alexandra%22">Sirota-Madi, Alexandra</searchLink><br /><searchLink fieldCode="AR" term="%22Thaiss%2C+Christoph+A%2E%22">Thaiss, Christoph A.</searchLink><br /><searchLink fieldCode="AR" term="%22Pevsner-Fischer%2C+Meirav%22">Pevsner-Fischer, Meirav</searchLink><br /><searchLink fieldCode="AR" term="%22Sorek%2C+Rotem%22">Sorek, Rotem</searchLink><br /><searchLink fieldCode="AR" term="%22Xavier%2C+Ramnik+J%2E%22">Xavier, Ramnik J.</searchLink><br /><searchLink fieldCode="AR" term="%22Elinav%2C+Eran%22">Elinav, Eran</searchLink><br /><searchLink fieldCode="AR" term="%22Segal%2C+Eran%22">Segal, Eran</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 9/4/2015, Vol. 349 Issue 6252, p1101-1106. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Microbiota%22">Microbiota</searchLink><br /><searchLink fieldCode="DE" term="%22Metagenomics%22">Metagenomics</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+growth%22">Bacterial growth</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+reproduction%22">Bacterial reproduction</searchLink><br /><searchLink fieldCode="DE" term="%22Gut+microbiota%22">Gut microbiota</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammatory+bowel+diseases%22">Inflammatory bowel diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Type+2+diabetes%22">Type 2 diabetes</searchLink>
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  Data: Metagenomic sequencing increased our understanding of the role of the microbiome in health and disease, yet it only provides a snapshot of a highly dynamic ecosystem. Here, we show that the pattern of metagenomic sequencing read coverage for different microbial genomes contains a single trough and a single peak, the latter coinciding with the bacterial origin of replication. Furthermore, the ratio of sequencing coverage between the peak and trough provides a quantitative measure of a species' growth rate. We demonstrate this in vitro and in vivo, under different growth conditions, and in complex bacterial communities. For several bacterial species, peak-to-trough coverage ratios, but not relative abundances, correlated with the manifestation of inflammatory bowel disease and type II diabetes. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=109277459
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        Value: 10.1126/science.aac4812
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        Text: English
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      – SubjectFull: Metagenomics
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      – SubjectFull: Bacterial growth
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      – SubjectFull: Bacterial reproduction
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      – SubjectFull: Gut microbiota
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      – SubjectFull: Type 2 diabetes
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