Bibliographic Details
| Title: |
SEROTONIN REDUCES POTASSIUM CURRENT IN RUTABAGA AND WILD-TYPE DROSOPHILA NEURONS. |
| Authors: |
Alshuaib, Waleed B., Mathew, Mini V., Hasan, Mohamed Y., Fahim, Mohamed A. |
| Source: |
International Journal of Neuroscience. 2003, Vol. 113 Issue 10, p1413. 13p. |
| Subjects: |
Drosophila, Rutabaga, Serotonin, Potassium |
| Abstract: |
The Drosophila learning mutant rutabaga is defective in short-term memory and has a reduced intracellular cyclic adenosine monophosphate (cAMP) concentration. The delayed-rectifier potassium current (IKDR) was measured from cultured (2 days) wild-type and rutabaga neurons. IKDR was smaller in rutabaga neurons (382 ± 41 pA) than in wild-type neurons (542 ± 33 pA). IKDR was measured from neurons before and after addition of serotonin to the external solution. IKDR was reduced by serotonin in wildtype (↓37 ± 7%) and rutabaga (↓33 ± 6%) neurons (single-cell studies). In the presence of serotonin, IKDR was smaller in rutabaga (218 ± 24 pA) than in wild-type (426 ± 35 pA) neurons (population studies). These results indicate that serotonin has affected IKDR so that the inherent difference between the two genotypes was preserved. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
