SEROTONIN REDUCES POTASSIUM CURRENT IN RUTABAGA AND WILD-TYPE DROSOPHILA NEURONS.
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| Title: | SEROTONIN REDUCES POTASSIUM CURRENT IN RUTABAGA AND WILD-TYPE DROSOPHILA NEURONS. |
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| Authors: | Alshuaib, Waleed B., Mathew, Mini V., Hasan, Mohamed Y., Fahim, Mohamed A. |
| Source: | International Journal of Neuroscience. 2003, Vol. 113 Issue 10, p1413. 13p. |
| Subjects: | Drosophila, Rutabaga, Serotonin, Potassium |
| Abstract: | The Drosophila learning mutant rutabaga is defective in short-term memory and has a reduced intracellular cyclic adenosine monophosphate (cAMP) concentration. The delayed-rectifier potassium current (IKDR) was measured from cultured (2 days) wild-type and rutabaga neurons. IKDR was smaller in rutabaga neurons (382 ± 41 pA) than in wild-type neurons (542 ± 33 pA). IKDR was measured from neurons before and after addition of serotonin to the external solution. IKDR was reduced by serotonin in wildtype (↓37 ± 7%) and rutabaga (↓33 ± 6%) neurons (single-cell studies). In the presence of serotonin, IKDR was smaller in rutabaga (218 ± 24 pA) than in wild-type (426 ± 35 pA) neurons (population studies). These results indicate that serotonin has affected IKDR so that the inherent difference between the two genotypes was preserved. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 11093519 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: SEROTONIN REDUCES POTASSIUM CURRENT IN RUTABAGA AND WILD-TYPE DROSOPHILA NEURONS. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Alshuaib%2C+Waleed+B%2E%22">Alshuaib, Waleed B.</searchLink><br /><searchLink fieldCode="AR" term="%22Mathew%2C+Mini+V%2E%22">Mathew, Mini V.</searchLink><br /><searchLink fieldCode="AR" term="%22Hasan%2C+Mohamed+Y%2E%22">Hasan, Mohamed Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Fahim%2C+Mohamed+A%2E%22">Fahim, Mohamed A.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. 2003, Vol. 113 Issue 10, p1413. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Drosophila%22">Drosophila</searchLink><br /><searchLink fieldCode="DE" term="%22Rutabaga%22">Rutabaga</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin%22">Serotonin</searchLink><br /><searchLink fieldCode="DE" term="%22Potassium%22">Potassium</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The Drosophila learning mutant rutabaga is defective in short-term memory and has a reduced intracellular cyclic adenosine monophosphate (cAMP) concentration. The delayed-rectifier potassium current (IKDR) was measured from cultured (2 days) wild-type and rutabaga neurons. IKDR was smaller in rutabaga neurons (382 ± 41 pA) than in wild-type neurons (542 ± 33 pA). IKDR was measured from neurons before and after addition of serotonin to the external solution. IKDR was reduced by serotonin in wild­type (↓37 ± 7%) and rutabaga (↓33 ± 6%) neurons (single-cell studies). In the presence of serotonin, IKDR was smaller in rutabaga (218 ± 24 pA) than in wild-type (426 ± 35 pA) neurons (population studies). These results indicate that serotonin has affected IKDR so that the inherent difference between the two genotypes was preserved.­­ [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/00207450390242787 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1413 Subjects: – SubjectFull: Drosophila Type: general – SubjectFull: Rutabaga Type: general – SubjectFull: Serotonin Type: general – SubjectFull: Potassium Type: general Titles: – TitleFull: SEROTONIN REDUCES POTASSIUM CURRENT IN RUTABAGA AND WILD-TYPE DROSOPHILA NEURONS. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Alshuaib, Waleed B. – PersonEntity: Name: NameFull: Mathew, Mini V. – PersonEntity: Name: NameFull: Hasan, Mohamed Y. – PersonEntity: Name: NameFull: Fahim, Mohamed A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: 2003 Type: published Y: 2003 Identifiers: – Type: issn-print Value: 00207454 Numbering: – Type: volume Value: 113 – Type: issue Value: 10 Titles: – TitleFull: International Journal of Neuroscience Type: main |
| ResultId | 1 |
