Metabolic syndrome in first-time hospitalized patients with depression: a 1-year follow-up study.

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Title:	Metabolic syndrome in first-time hospitalized patients with depression: a 1-year follow-up study.
Authors:	Nyboe, L., Vestergaard, C. H., Lund, H., Møller, M. K., Videbech, P.
Source:	Acta Psychiatrica Scandinavica. Mar2016, Vol. 133 Issue 3, p241-248. 8p. 5 Charts.
Subjects:	Depressed persons, Metabolic syndrome, Metabolic syndrome risk factors, Antipsychotic agents, Hospital patients, Physiological aspects of physical fitness, Disease prevalence, Diseases, Patients
Abstract:	Objective Studies on metabolic syndrome (MetS) in younger patients with depression are few. We examined the prevalence and progression of MetS in first-time hospitalized patients with depression during 1 year of follow-up. Furthermore, we explored putative risk factors of MetS. Method We evaluated MetS and its components in first-time hospitalized patients with depression ( N = 52) and healthy controls ( N = 50) (18-45 years). Physical activity, aerobic fitness, sleeping disturbances, smoking and dietary habits, and psychopharmacological treatment were recorded at baseline for all participants and after 1 year for the patients. Results Patients had significantly higher waist circumference ( WC) and lower high-density lipoproteins compared with healthy controls ( P < 0.05). Patients had higher prevalence of MetS, but this was not significant when adjusted for age. Patients had significant increase in WC and triglycerides and a non-significant increase in the prevalence of MetS. Antipsychotic medication ( OR 10.5, 95% CI 1.18-94.14) and low aerobic fitness ( OR 0.79, 95% CI 0.68-0.93) were significantly correlated with MetS ( P < 0.05). Conclusion Metabolic syndrome is highly prevalent in younger, severely depressed patients and the incidence increases during 1 year of follow-up. Low aerobic fitness and use of atypical antipsychotics are strongly correlated with MetS. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

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Abstract:	Objective Studies on metabolic syndrome (MetS) in younger patients with depression are few. We examined the prevalence and progression of MetS in first-time hospitalized patients with depression during 1 year of follow-up. Furthermore, we explored putative risk factors of MetS. Method We evaluated MetS and its components in first-time hospitalized patients with depression ( N = 52) and healthy controls ( N = 50) (18-45 years). Physical activity, aerobic fitness, sleeping disturbances, smoking and dietary habits, and psychopharmacological treatment were recorded at baseline for all participants and after 1 year for the patients. Results Patients had significantly higher waist circumference ( WC) and lower high-density lipoproteins compared with healthy controls ( P < 0.05). Patients had higher prevalence of MetS, but this was not significant when adjusted for age. Patients had significant increase in WC and triglycerides and a non-significant increase in the prevalence of MetS. Antipsychotic medication ( OR 10.5, 95% CI 1.18-94.14) and low aerobic fitness ( OR 0.79, 95% CI 0.68-0.93) were significantly correlated with MetS ( P < 0.05). Conclusion Metabolic syndrome is highly prevalent in younger, severely depressed patients and the incidence increases during 1 year of follow-up. Low aerobic fitness and use of atypical antipsychotics are strongly correlated with MetS. [ABSTRACT FROM AUTHOR]
ISSN:	0001690X
DOI:	10.1111/acps.12470