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Brain connectome modularity in weight-restored anorexia nervosa and body dysmorphic disorder.

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Bibliographic Details
Title: Brain connectome modularity in weight-restored anorexia nervosa and body dysmorphic disorder.
Authors: Zhang, A., Leow, A., Zhan, L., GadElkarim, J., Moody, T., Khalsa, S., Strober, M., Feusner, J. D.
Source: Psychological Medicine. Oct2016, Vol. 46 Issue 13, p2785-2797. 13p.
Subjects: Radiography, Anorexia nervosa, Body dysmorphic disorder, Brain, Comparative studies, Magnetic resonance imaging
Abstract: BackgroundAnorexia nervosa (AN) and body dysmorphic disorder (BDD) frequently co-occur, and have several overlapping phenomenological features. Little is known about their shared neurobiology. The aim of the study was to compare modular organization of brain structural connectivity.MethodWe acquired diffusion-weighted magnetic resonance imaging data on unmedicated individuals with BDD (n = 29), weight-restored AN (n = 24) and healthy controls (HC) (n = 31). We constructed connectivity matrices using whole-brain white matter tractography, and compared modular structures across groups.ResultsAN showed abnormal modularity involving frontal, basal ganglia and posterior cingulate nodes. There was a trend in BDD for similar abnormalities, but no significant differences compared with AN. In AN, poor insight correlated with longer path length in right caudal anterior cingulate and right posterior cingulate.ConclusionsAbnormal network organization patterns in AN, partially shared with BDD, may have implications for understanding integration between reward and habit/ritual formation, as well as conflict monitoring/error detection. [ABSTRACT FROM AUTHOR]
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Database: Psychology and Behavioral Sciences Collection
Description
Abstract:BackgroundAnorexia nervosa (AN) and body dysmorphic disorder (BDD) frequently co-occur, and have several overlapping phenomenological features. Little is known about their shared neurobiology. The aim of the study was to compare modular organization of brain structural connectivity.MethodWe acquired diffusion-weighted magnetic resonance imaging data on unmedicated individuals with BDD (n = 29), weight-restored AN (n = 24) and healthy controls (HC) (n = 31). We constructed connectivity matrices using whole-brain white matter tractography, and compared modular structures across groups.ResultsAN showed abnormal modularity involving frontal, basal ganglia and posterior cingulate nodes. There was a trend in BDD for similar abnormalities, but no significant differences compared with AN. In AN, poor insight correlated with longer path length in right caudal anterior cingulate and right posterior cingulate.ConclusionsAbnormal network organization patterns in AN, partially shared with BDD, may have implications for understanding integration between reward and habit/ritual formation, as well as conflict monitoring/error detection. [ABSTRACT FROM AUTHOR]
ISSN:00332917
DOI:10.1017/S0033291716001458