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Brain connectome modularity in weight-restored anorexia nervosa and body dysmorphic disorder.

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Title: Brain connectome modularity in weight-restored anorexia nervosa and body dysmorphic disorder.
Authors: Zhang, A., Leow, A., Zhan, L., GadElkarim, J., Moody, T., Khalsa, S., Strober, M., Feusner, J. D.
Source: Psychological Medicine. Oct2016, Vol. 46 Issue 13, p2785-2797. 13p.
Subjects: Radiography, Anorexia nervosa, Body dysmorphic disorder, Brain, Comparative studies, Magnetic resonance imaging
Abstract: BackgroundAnorexia nervosa (AN) and body dysmorphic disorder (BDD) frequently co-occur, and have several overlapping phenomenological features. Little is known about their shared neurobiology. The aim of the study was to compare modular organization of brain structural connectivity.MethodWe acquired diffusion-weighted magnetic resonance imaging data on unmedicated individuals with BDD (n = 29), weight-restored AN (n = 24) and healthy controls (HC) (n = 31). We constructed connectivity matrices using whole-brain white matter tractography, and compared modular structures across groups.ResultsAN showed abnormal modularity involving frontal, basal ganglia and posterior cingulate nodes. There was a trend in BDD for similar abnormalities, but no significant differences compared with AN. In AN, poor insight correlated with longer path length in right caudal anterior cingulate and right posterior cingulate.ConclusionsAbnormal network organization patterns in AN, partially shared with BDD, may have implications for understanding integration between reward and habit/ritual formation, as well as conflict monitoring/error detection. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
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  Data: Brain connectome modularity in weight-restored anorexia nervosa and body dysmorphic disorder.
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  Data: <searchLink fieldCode="AR" term="%22Zhang%2C+A%2E%22">Zhang, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Leow%2C+A%2E%22">Leow, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhan%2C+L%2E%22">Zhan, L.</searchLink><br /><searchLink fieldCode="AR" term="%22GadElkarim%2C+J%2E%22">GadElkarim, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Moody%2C+T%2E%22">Moody, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Khalsa%2C+S%2E%22">Khalsa, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Strober%2C+M%2E%22">Strober, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Feusner%2C+J%2E+D%2E%22">Feusner, J. D.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Oct2016, Vol. 46 Issue 13, p2785-2797. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Radiography%22">Radiography</searchLink><br /><searchLink fieldCode="DE" term="%22Anorexia+nervosa%22">Anorexia nervosa</searchLink><br /><searchLink fieldCode="DE" term="%22Body+dysmorphic+disorder%22">Body dysmorphic disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: BackgroundAnorexia nervosa (AN) and body dysmorphic disorder (BDD) frequently co-occur, and have several overlapping phenomenological features. Little is known about their shared neurobiology. The aim of the study was to compare modular organization of brain structural connectivity.MethodWe acquired diffusion-weighted magnetic resonance imaging data on unmedicated individuals with BDD (n = 29), weight-restored AN (n = 24) and healthy controls (HC) (n = 31). We constructed connectivity matrices using whole-brain white matter tractography, and compared modular structures across groups.ResultsAN showed abnormal modularity involving frontal, basal ganglia and posterior cingulate nodes. There was a trend in BDD for similar abnormalities, but no significant differences compared with AN. In AN, poor insight correlated with longer path length in right caudal anterior cingulate and right posterior cingulate.ConclusionsAbnormal network organization patterns in AN, partially shared with BDD, may have implications for understanding integration between reward and habit/ritual formation, as well as conflict monitoring/error detection. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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