Bibliographic Details
| Title: |
Sertraline in paired blood plasma and breast-milk samples from nursing mothers. |
| Authors: |
Dodd, Seetal, Stocky, Andrew, Buist, Anne, Burrows, Graham D., Maguire, Kay, Norman, Trevor R. |
| Source: |
Human Psychopharmacology: Clinical & Experimental. Jun2000, Vol. 15 Issue 4, p161-264. 104p. 1 Chart. |
| Subjects: |
Breast milk, Sertraline, High performance liquid chromatography, Liquid chromatography, Blood plasma |
| Abstract: |
Paired blood and breast-milk samples were collected from 10 nursing mothers receiving sertraline. Samples were collected at steady state when the patients had been taking stable doses of 50–150 mg/day over several weeks. Sertraline concentrations in both fluids were determined using a specific, validated HPLC method. Plasma and milk concentrations showed a wide inter-individual variability for the same dose. Mean plasma concentrations were linearly related to dose, but this was not the case for breast-milk concentrations. An overall milk to plasma ratio of 1·76±1·72 was recorded. The average dose to the infants ranged from 1·1 to 31·1 μg/kg, which is less than 2 per cent of the maternal dose per day. Further studies are necessary to determine if these doses are detrimental to the development of the infant. Copyright © 2000 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
|
Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Psychology and Behavioral Sciences Collection |
