View in EDS PDF Full Text

Sertraline in paired blood plasma and breast-milk samples from nursing mothers.

Saved in:
Bibliographic Details
Title: Sertraline in paired blood plasma and breast-milk samples from nursing mothers.
Authors: Dodd, Seetal, Stocky, Andrew, Buist, Anne, Burrows, Graham D., Maguire, Kay, Norman, Trevor R.
Source: Human Psychopharmacology: Clinical & Experimental. Jun2000, Vol. 15 Issue 4, p161-264. 104p. 1 Chart.
Subjects: Breast milk, Sertraline, High performance liquid chromatography, Liquid chromatography, Blood plasma
Abstract: Paired blood and breast-milk samples were collected from 10 nursing mothers receiving sertraline. Samples were collected at steady state when the patients had been taking stable doses of 50–150 mg/day over several weeks. Sertraline concentrations in both fluids were determined using a specific, validated HPLC method. Plasma and milk concentrations showed a wide inter-individual variability for the same dose. Mean plasma concentrations were linearly related to dose, but this was not the case for breast-milk concentrations. An overall milk to plasma ratio of 1·76±1·72 was recorded. The average dose to the infants ranged from 1·1 to 31·1 μg/kg, which is less than 2 per cent of the maternal dose per day. Further studies are necessary to determine if these doses are detrimental to the development of the infant. Copyright © 2000 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 11822244
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Sertraline in paired blood plasma and breast-milk samples from nursing mothers.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Dodd%2C+Seetal%22">Dodd, Seetal</searchLink><br /><searchLink fieldCode="AR" term="%22Stocky%2C+Andrew%22">Stocky, Andrew</searchLink><br /><searchLink fieldCode="AR" term="%22Buist%2C+Anne%22">Buist, Anne</searchLink><br /><searchLink fieldCode="AR" term="%22Burrows%2C+Graham+D%2E%22">Burrows, Graham D.</searchLink><br /><searchLink fieldCode="AR" term="%22Maguire%2C+Kay%22">Maguire, Kay</searchLink><br /><searchLink fieldCode="AR" term="%22Norman%2C+Trevor+R%2E%22">Norman, Trevor R.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Human+Psychopharmacology%3A+Clinical+%26+Experimental%22">Human Psychopharmacology: Clinical & Experimental</searchLink>. Jun2000, Vol. 15 Issue 4, p161-264. 104p. 1 Chart.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Breast+milk%22">Breast milk</searchLink><br /><searchLink fieldCode="DE" term="%22Sertraline%22">Sertraline</searchLink><br /><searchLink fieldCode="DE" term="%22High+performance+liquid+chromatography%22">High performance liquid chromatography</searchLink><br /><searchLink fieldCode="DE" term="%22Liquid+chromatography%22">Liquid chromatography</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+plasma%22">Blood plasma</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Paired blood and breast-milk samples were collected from 10 nursing mothers receiving sertraline. Samples were collected at steady state when the patients had been taking stable doses of 50–150 mg/day over several weeks. Sertraline concentrations in both fluids were determined using a specific, validated HPLC method. Plasma and milk concentrations showed a wide inter-individual variability for the same dose. Mean plasma concentrations were linearly related to dose, but this was not the case for breast-milk concentrations. An overall milk to plasma ratio of 1·76±1·72 was recorded. The average dose to the infants ranged from 1·1 to 31·1 μg/kg, which is less than 2 per cent of the maternal dose per day. Further studies are necessary to determine if these doses are detrimental to the development of the infant. Copyright © 2000 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=11822244
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/1099-1077(200006)15:4<161::AID-HUP167>3.0.CO;2-2
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 104
        StartPage: 161
    Subjects:
      – SubjectFull: Breast milk
        Type: general
      – SubjectFull: Sertraline
        Type: general
      – SubjectFull: High performance liquid chromatography
        Type: general
      – SubjectFull: Liquid chromatography
        Type: general
      – SubjectFull: Blood plasma
        Type: general
    Titles:
      – TitleFull: Sertraline in paired blood plasma and breast-milk samples from nursing mothers.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Dodd, Seetal
      – PersonEntity:
          Name:
            NameFull: Stocky, Andrew
      – PersonEntity:
          Name:
            NameFull: Buist, Anne
      – PersonEntity:
          Name:
            NameFull: Burrows, Graham D.
      – PersonEntity:
          Name:
            NameFull: Maguire, Kay
      – PersonEntity:
          Name:
            NameFull: Norman, Trevor R.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2000
              Type: published
              Y: 2000
          Identifiers:
            – Type: issn-print
              Value: 08856222
          Numbering:
            – Type: volume
              Value: 15
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Human Psychopharmacology: Clinical & Experimental
              Type: main
ResultId 1