View in EDS PDF Full Text

Duloxetine in elderly major depression disorder: effectiveness and drug plasma level evaluation.

Saved in:
Bibliographic Details
Title: Duloxetine in elderly major depression disorder: effectiveness and drug plasma level evaluation.
Authors: Rovera, Chiara, Mauri, Massimo Carlo, Bertin, Elena, Di Pace, Chiara, Paletta, Silvia, Reggiori, Alessandra, De Gaspari, Ilaria Francesca, Cattaneo, Dario, Mari, Daniela, Altamura, Alfredo Carlo
Source: Human Psychopharmacology: Clinical & Experimental. Sep2016, Vol. 31 Issue 5, p349-355. 7p.
Subjects: Mental depression, Therapeutics, Duloxetine, Mental health of older people, Drug efficacy, Blood plasma
Abstract: Objective The aim of this open-label naturalistic study was to assess clinical outcomes and the predictive value of duloxetine plasma levels in major depressive disorder in the elderly. Methods This naturalistic, open-label design involved 35 outpatients aged between 65 and 87 years. Duloxetine plasma levels were collected in 24 patients after the first month. Patients were evaluated using 21-item Hamilton Rating Scales for Depression, Hamilton Rating Scales for Anxiety, the Clinical Global Impression Severity, Mini Mental State Examination, Cumulative Illness Rating Scale, Barthel Index and Beck's Depression Inventory. Results Duloxetine plasma levels at T2 ranged from 4.9 to 201.9 ng/mL without a significant correlation between duloxetine dose and plasma levels. A significant improvement in mean 21-item Hamilton Rating Scales for Depression total scores at T2,T3, T4, T9 and T12 and a progressive significantly decrease of the mean Hamilton Rating Scales for Anxiety scores from T3 to T12 were observed. Conclusions The levels of duloxetine in plasma do not correlate with a greater clinical improvement, indeed appear to adversely affect the improvement of the Beck Depression Inventory and Hamilton Rating Scales for Anxiety. This could be explained by an increase in side effects that may aggravate the discomfort felt by the patient. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 118222821
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Duloxetine in elderly major depression disorder: effectiveness and drug plasma level evaluation.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Rovera%2C+Chiara%22">Rovera, Chiara</searchLink><br /><searchLink fieldCode="AR" term="%22Mauri%2C+Massimo+Carlo%22">Mauri, Massimo Carlo</searchLink><br /><searchLink fieldCode="AR" term="%22Bertin%2C+Elena%22">Bertin, Elena</searchLink><br /><searchLink fieldCode="AR" term="%22Di+Pace%2C+Chiara%22">Di Pace, Chiara</searchLink><br /><searchLink fieldCode="AR" term="%22Paletta%2C+Silvia%22">Paletta, Silvia</searchLink><br /><searchLink fieldCode="AR" term="%22Reggiori%2C+Alessandra%22">Reggiori, Alessandra</searchLink><br /><searchLink fieldCode="AR" term="%22De+Gaspari%2C+Ilaria+Francesca%22">De Gaspari, Ilaria Francesca</searchLink><br /><searchLink fieldCode="AR" term="%22Cattaneo%2C+Dario%22">Cattaneo, Dario</searchLink><br /><searchLink fieldCode="AR" term="%22Mari%2C+Daniela%22">Mari, Daniela</searchLink><br /><searchLink fieldCode="AR" term="%22Altamura%2C+Alfredo+Carlo%22">Altamura, Alfredo Carlo</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Human+Psychopharmacology%3A+Clinical+%26+Experimental%22">Human Psychopharmacology: Clinical & Experimental</searchLink>. Sep2016, Vol. 31 Issue 5, p349-355. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Duloxetine%22">Duloxetine</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health+of+older+people%22">Mental health of older people</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+efficacy%22">Drug efficacy</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+plasma%22">Blood plasma</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective The aim of this open-label naturalistic study was to assess clinical outcomes and the predictive value of duloxetine plasma levels in major depressive disorder in the elderly. Methods This naturalistic, open-label design involved 35 outpatients aged between 65 and 87 years. Duloxetine plasma levels were collected in 24 patients after the first month. Patients were evaluated using 21-item Hamilton Rating Scales for Depression, Hamilton Rating Scales for Anxiety, the Clinical Global Impression Severity, Mini Mental State Examination, Cumulative Illness Rating Scale, Barthel Index and Beck's Depression Inventory. Results Duloxetine plasma levels at T2 ranged from 4.9 to 201.9 ng/mL without a significant correlation between duloxetine dose and plasma levels. A significant improvement in mean 21-item Hamilton Rating Scales for Depression total scores at T2,T3, T4, T9 and T12 and a progressive significantly decrease of the mean Hamilton Rating Scales for Anxiety scores from T3 to T12 were observed. Conclusions The levels of duloxetine in plasma do not correlate with a greater clinical improvement, indeed appear to adversely affect the improvement of the Beck Depression Inventory and Hamilton Rating Scales for Anxiety. This could be explained by an increase in side effects that may aggravate the discomfort felt by the patient. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=118222821
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/hup.2544
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 349
    Subjects:
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Therapeutics
        Type: general
      – SubjectFull: Duloxetine
        Type: general
      – SubjectFull: Mental health of older people
        Type: general
      – SubjectFull: Drug efficacy
        Type: general
      – SubjectFull: Blood plasma
        Type: general
    Titles:
      – TitleFull: Duloxetine in elderly major depression disorder: effectiveness and drug plasma level evaluation.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Rovera, Chiara
      – PersonEntity:
          Name:
            NameFull: Mauri, Massimo Carlo
      – PersonEntity:
          Name:
            NameFull: Bertin, Elena
      – PersonEntity:
          Name:
            NameFull: Di Pace, Chiara
      – PersonEntity:
          Name:
            NameFull: Paletta, Silvia
      – PersonEntity:
          Name:
            NameFull: Reggiori, Alessandra
      – PersonEntity:
          Name:
            NameFull: De Gaspari, Ilaria Francesca
      – PersonEntity:
          Name:
            NameFull: Cattaneo, Dario
      – PersonEntity:
          Name:
            NameFull: Mari, Daniela
      – PersonEntity:
          Name:
            NameFull: Altamura, Alfredo Carlo
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: Sep2016
              Type: published
              Y: 2016
          Identifiers:
            – Type: issn-print
              Value: 08856222
          Numbering:
            – Type: volume
              Value: 31
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Human Psychopharmacology: Clinical & Experimental
              Type: main
ResultId 1