Prognostic factors in children with PRES and hematologic diseases.
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| Title: | Prognostic factors in children with PRES and hematologic diseases. |
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| Authors: | Tambasco, N., Mastrodicasa, E., Salvatori, C., Mancini, G., Romoli, M., Caniglia, M., Calabresi, P., Verrotti, A. |
| Source: | Acta Neurologica Scandinavica. Dec2016, Vol. 134 Issue 6, p474-483. 10p. |
| Subjects: | Blood diseases, Posterior leukoencephalopathy syndrome, Brain imaging, Electroencephalography, Health outcome assessment, Magnetic resonance imaging, Prognosis |
| Abstract: | Objectives Posterior reversible encephalopathy syndrome ( PRES) is a clinical and radiological entity characterized by focal neurological signs, headache, confusion, and seizure, associated with transitory lesions in the posterior areas of the brain detectable with neuroimaging. Among children, one of the most common causes of PRES is cancer. Materials and Methods In this review, we present the cases of 5 children developing PRES after stem cell transplantation for hematological disease and review all the cases reported in English literature to investigate outcomes and associated risk factors. Results One hundred and eleven cases were reported. Hypertension was very frequent (80%). Clinical features included seizures (80.1%), headache (44.1%), visual disturbance (26.1%), and mental change (48.6%). EEG was abnormal in 27 of 32 patients. MRI revealed characteristic lesions in all patients even in early stages. Abnormal MRI findings in late stages were associated with neurological sequelae. Nineteen patients died (17.1%) of which 2 of PRES. Among alive patients, 17 had neurological sequelae. Four cases of PRES relapse were described. Conclusions Thus, all transplant recipients with symptoms consistent with PRES should be promptly recognized to avoid long-term complications or even death. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objectives Posterior reversible encephalopathy syndrome ( PRES) is a clinical and radiological entity characterized by focal neurological signs, headache, confusion, and seizure, associated with transitory lesions in the posterior areas of the brain detectable with neuroimaging. Among children, one of the most common causes of PRES is cancer. Materials and Methods In this review, we present the cases of 5 children developing PRES after stem cell transplantation for hematological disease and review all the cases reported in English literature to investigate outcomes and associated risk factors. Results One hundred and eleven cases were reported. Hypertension was very frequent (80%). Clinical features included seizures (80.1%), headache (44.1%), visual disturbance (26.1%), and mental change (48.6%). EEG was abnormal in 27 of 32 patients. MRI revealed characteristic lesions in all patients even in early stages. Abnormal MRI findings in late stages were associated with neurological sequelae. Nineteen patients died (17.1%) of which 2 of PRES. Among alive patients, 17 had neurological sequelae. Four cases of PRES relapse were described. Conclusions Thus, all transplant recipients with symptoms consistent with PRES should be promptly recognized to avoid long-term complications or even death. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00016314 |
| DOI: | 10.1111/ane.12570 |
