Bibliographic Details
| Title: |
Effects of Serotonin Receptor Agonists and Antagonists on Offensive Aggression in Mice. |
| Authors: |
Lindgren, Tone, Kantak, Kathleen M. |
| Source: |
Aggressive Behavior. 1987, Vol. 13 Issue 2, p87-96. 10p. |
| Subjects: |
Serotonin antagonists, Aggression (Psychology), Mice anatomy, Contact inhibition, Psychological research, Neurosciences |
| Abstract: |
The effects of serotonin receptor agonist 5-methoxytryptamine and quipazine, and antagonist mianserin on resident-intruder offensive aggression were investigated. Both agonist reduced aggression. The fact that 5-methoxytryptamine preferentially binds to 5-HT-1 receptors strongly suggest that the decreased aggression with 5-methoxytryptamine was related to stimulation of an inhibition 5-HT-1 receptor. It is also suggested that the reduction in aggression with quipazine was related to quipazine’s preferential bindings to the 5-HT-1 receptor. The 5-HT-2 receptor antagonist mianserin reduced aggression suggesting that 5-HT-2 receptor blockade is inhibitory for aggression. Thus, two serotonin classes of receptors may be differentially involved in offensive aggression. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
