Effects of Serotonin Receptor Agonists and Antagonists on Offensive Aggression in Mice.
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| Title: | Effects of Serotonin Receptor Agonists and Antagonists on Offensive Aggression in Mice. |
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| Authors: | Lindgren, Tone, Kantak, Kathleen M. |
| Source: | Aggressive Behavior. 1987, Vol. 13 Issue 2, p87-96. 10p. |
| Subjects: | Serotonin antagonists, Aggression (Psychology), Mice anatomy, Contact inhibition, Psychological research, Neurosciences |
| Abstract: | The effects of serotonin receptor agonist 5-methoxytryptamine and quipazine, and antagonist mianserin on resident-intruder offensive aggression were investigated. Both agonist reduced aggression. The fact that 5-methoxytryptamine preferentially binds to 5-HT-1 receptors strongly suggest that the decreased aggression with 5-methoxytryptamine was related to stimulation of an inhibition 5-HT-1 receptor. It is also suggested that the reduction in aggression with quipazine was related to quipazine’s preferential bindings to the 5-HT-1 receptor. The 5-HT-2 receptor antagonist mianserin reduced aggression suggesting that 5-HT-2 receptor blockade is inhibitory for aggression. Thus, two serotonin classes of receptors may be differentially involved in offensive aggression. [ABSTRACT FROM AUTHOR] |
| Copyright of Aggressive Behavior is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 11946877 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of Serotonin Receptor Agonists and Antagonists on Offensive Aggression in Mice. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lindgren%2C+Tone%22">Lindgren, Tone</searchLink><br /><searchLink fieldCode="AR" term="%22Kantak%2C+Kathleen+M%2E%22">Kantak, Kathleen M.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Aggressive+Behavior%22">Aggressive Behavior</searchLink>. 1987, Vol. 13 Issue 2, p87-96. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Serotonin+antagonists%22">Serotonin antagonists</searchLink><br /><searchLink fieldCode="DE" term="%22Aggression+%28Psychology%29%22">Aggression (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Mice+anatomy%22">Mice anatomy</searchLink><br /><searchLink fieldCode="DE" term="%22Contact+inhibition%22">Contact inhibition</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+research%22">Psychological research</searchLink><br /><searchLink fieldCode="DE" term="%22Neurosciences%22">Neurosciences</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The effects of serotonin receptor agonist 5-methoxytryptamine and quipazine, and antagonist mianserin on resident-intruder offensive aggression were investigated. Both agonist reduced aggression. The fact that 5-methoxytryptamine preferentially binds to 5-HT-1 receptors strongly suggest that the decreased aggression with 5-methoxytryptamine was related to stimulation of an inhibition 5-HT-1 receptor. It is also suggested that the reduction in aggression with quipazine was related to quipazine’s preferential bindings to the 5-HT-1 receptor. The 5-HT-2 receptor antagonist mianserin reduced aggression suggesting that 5-HT-2 receptor blockade is inhibitory for aggression. Thus, two serotonin classes of receptors may be differentially involved in offensive aggression. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Aggressive Behavior is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=11946877 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/1098-2337(1987)13:2<87::AID-AB2480130205>3.0.CO;2-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 87 Subjects: – SubjectFull: Serotonin antagonists Type: general – SubjectFull: Aggression (Psychology) Type: general – SubjectFull: Mice anatomy Type: general – SubjectFull: Contact inhibition Type: general – SubjectFull: Psychological research Type: general – SubjectFull: Neurosciences Type: general Titles: – TitleFull: Effects of Serotonin Receptor Agonists and Antagonists on Offensive Aggression in Mice. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lindgren, Tone – PersonEntity: Name: NameFull: Kantak, Kathleen M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 1987 Type: published Y: 1987 Identifiers: – Type: issn-print Value: 0096140X Numbering: – Type: volume Value: 13 – Type: issue Value: 2 Titles: – TitleFull: Aggressive Behavior Type: main |
| ResultId | 1 |
