Common variants of APOE are associated with anti-epileptic drugs resistance in Han Chinese patients.
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| Title: | Common variants of APOE are associated with anti-epileptic drugs resistance in Han Chinese patients. |
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| Authors: | Gong, Jiao-E (AUTHOR), Qu, Jian (AUTHOR), Long, Hong-Yu (AUTHOR), Long, Li-Li (AUTHOR), Qu, Qiang (AUTHOR), Li, Xiang-Ming (AUTHOR), Yang, Li-Ming (AUTHOR), Xiao, Bo (AUTHOR) |
| Source: | International Journal of Neuroscience. Jan2017, Vol. 127 Issue 1, p14-19. 6p. |
| Subjects: | Apolipoprotein E, Anticonvulsants, Alleles, Drug resistance, Genotypes |
| Abstract: | Purpose/aim of the study: Apolipoprotein E (APOE) has been implicated as one of the susceptibility genes for some subtypes of epilepsy and may be related to anti-epileptic drugs resistance. The purpose of this study was to investigate the possible association betweenAPOEvariants and the anti-epileptic drugs resistance in Chinese population.Materials and methods:APOEgene rs429358 and rs7412 variants were genotyped forϵ2,ϵ3,ϵ4 alleles using amplification refractory mutation system in 480 subjects including 207 anti-epileptic drugs-resistant patients and 273 drug-responsive patients.Results: We found that the frequency ofAPOEgene rs429358 C allele in the drug resistant patients is higher than that in the drug-responsive patients (14.98% vs.10.1%, OR = 1.25[1.02 − 1.52],p = 0.017). Moreover, according to the two variants, we analyzed the distributions of −ϵ4 and +ϵ4 alleles ofAPOEgene and found that there were higher frequencies of +ϵ4 allele in drug-resistant epileptic patients than that in drug-responsive patients (31.8% vs.13.2%, OR = 1.15[1.05 − 1.25],p = 0.002).Conclusions: Our study demonstrated thatAPOErs429358 variant C allele andϵ4 allele were associated with the anti-epileptic drugs resistance in Han Chinese patients. [ABSTRACT FROM PUBLISHER] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Purpose/aim of the study: Apolipoprotein E (APOE) has been implicated as one of the susceptibility genes for some subtypes of epilepsy and may be related to anti-epileptic drugs resistance. The purpose of this study was to investigate the possible association betweenAPOEvariants and the anti-epileptic drugs resistance in Chinese population.Materials and methods:APOEgene rs429358 and rs7412 variants were genotyped forϵ2,ϵ3,ϵ4 alleles using amplification refractory mutation system in 480 subjects including 207 anti-epileptic drugs-resistant patients and 273 drug-responsive patients.Results: We found that the frequency ofAPOEgene rs429358 C allele in the drug resistant patients is higher than that in the drug-responsive patients (14.98% vs.10.1%, OR = 1.25[1.02 − 1.52],p = 0.017). Moreover, according to the two variants, we analyzed the distributions of −ϵ4 and +ϵ4 alleles ofAPOEgene and found that there were higher frequencies of +ϵ4 allele in drug-resistant epileptic patients than that in drug-responsive patients (31.8% vs.13.2%, OR = 1.15[1.05 − 1.25],p = 0.002).Conclusions: Our study demonstrated thatAPOErs429358 variant C allele andϵ4 allele were associated with the anti-epileptic drugs resistance in Han Chinese patients. [ABSTRACT FROM PUBLISHER] |
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| ISSN: | 00207454 |
| DOI: | 10.3109/00207454.2015.1137295 |
