The PRIAMO study: urinary dysfunction as a marker of disease progression in early Parkinson's disease.
Saved in:
| Title: | The PRIAMO study: urinary dysfunction as a marker of disease progression in early Parkinson's disease. |
|---|---|
| Authors: | Picillo, M., Palladino, R., Barone, P., Erro, R., Colosimo, C., Marconi, R., Morgante, L., Antonini, A. |
| Source: | European Journal of Neurology. Jun2017, Vol. 24 Issue 6, p788-795. 8p. 1 Chart, 2 Graphs. |
| Subjects: | Parkinson's disease diagnosis, Parkinson's disease patients, Symptoms, Urinary organ abnormalities, Movement disorders |
| Abstract: | Background and purpose New venues are currently being explored to predict disease progression in Parkinson's disease ( PD), such as non-motor subtypes and models merging motor and non-motor symptoms ( NMS). By involving a subgroup of 585 patients from the PRIAMO (Parkinson Disease Non-motor Symptoms) study, the present 24-month longitudinal prospective analysis aimed to demonstrate that urinary dysfunction is an early marker of higher motor and non-motor burden as well as lower health-related quality of life. Methods and results Multivariable mixed-effect logistic regression models controlling for demographic and clinical variables showed that the following NMS domains were associated with urinary dysfunction: gastrointestinal [odds ratio ( OR) 2.57, 95% confidence interval ( CI) 1.67-3.97, P < 0.001], cardiovascular ( OR 2.22, 95% CI 1.18-4.17, P = 0.013), skin ( OR 1.81, 95% CI 1.06-3.08, P = 0.029), sleep ( OR 2.06, 95% CI 1.34-3.16, P = 0.001), pain ( OR 1.85, 95% CI 1.21-2.83, P = 0.004), fatigue ( OR 2.40, 95% CI 1.56-3.68, P < 0.001), apathy ( OR 2.79, 95% CI 1.72-4.52, P < 0.001) and respiratory ( OR 1.82, 95% CI 1.02-3.23, P = 0.039). Analysis also demonstrated that urinary dysfunction was associated with higher motor disability (coefficient 1.73, 95% CI 0.68-2.78, P = 0.001) and lower health-related quality of life (coefficient −0.05, 95% CI −0.08 to −0.02, P < 0.001, and coefficient −3.49, 95% CI −5.21 to −1.77, P < 0.001) but not with more severe cognitive disability (coefficient −0.34, 95% CI −0.92 to 0.24, P = 0.251). Conclusions This is the first prospective longitudinal study involving a large cohort of PD patients demonstrating the relevance of urinary dysfunction as an early marker of higher motor and non-motor disability as well as lower health-related quality of life. These findings support a role for urinary dysfunction as an early marker of more severe disease progression. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| Abstract: | Background and purpose New venues are currently being explored to predict disease progression in Parkinson's disease ( PD), such as non-motor subtypes and models merging motor and non-motor symptoms ( NMS). By involving a subgroup of 585 patients from the PRIAMO (Parkinson Disease Non-motor Symptoms) study, the present 24-month longitudinal prospective analysis aimed to demonstrate that urinary dysfunction is an early marker of higher motor and non-motor burden as well as lower health-related quality of life. Methods and results Multivariable mixed-effect logistic regression models controlling for demographic and clinical variables showed that the following NMS domains were associated with urinary dysfunction: gastrointestinal [odds ratio ( OR) 2.57, 95% confidence interval ( CI) 1.67-3.97, P < 0.001], cardiovascular ( OR 2.22, 95% CI 1.18-4.17, P = 0.013), skin ( OR 1.81, 95% CI 1.06-3.08, P = 0.029), sleep ( OR 2.06, 95% CI 1.34-3.16, P = 0.001), pain ( OR 1.85, 95% CI 1.21-2.83, P = 0.004), fatigue ( OR 2.40, 95% CI 1.56-3.68, P < 0.001), apathy ( OR 2.79, 95% CI 1.72-4.52, P < 0.001) and respiratory ( OR 1.82, 95% CI 1.02-3.23, P = 0.039). Analysis also demonstrated that urinary dysfunction was associated with higher motor disability (coefficient 1.73, 95% CI 0.68-2.78, P = 0.001) and lower health-related quality of life (coefficient −0.05, 95% CI −0.08 to −0.02, P < 0.001, and coefficient −3.49, 95% CI −5.21 to −1.77, P < 0.001) but not with more severe cognitive disability (coefficient −0.34, 95% CI −0.92 to 0.24, P = 0.251). Conclusions This is the first prospective longitudinal study involving a large cohort of PD patients demonstrating the relevance of urinary dysfunction as an early marker of higher motor and non-motor disability as well as lower health-related quality of life. These findings support a role for urinary dysfunction as an early marker of more severe disease progression. [ABSTRACT FROM AUTHOR] |
|---|---|
| ISSN: | 13515101 |
| DOI: | 10.1111/ene.13290 |
