The central cannabinoid receptor type-2 (CB2) and chronic pain.
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| Title: | The central cannabinoid receptor type-2 (CB2) and chronic pain. |
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| Authors: | Shang, Yuchao (AUTHOR), Tang, Yuying (AUTHOR) |
| Source: | International Journal of Neuroscience. Sep2017, Vol. 127 Issue 9, p812-823. 12p. |
| Subjects: | Cannabinoid receptors, Chronic pain, Analgesia, Cytokines, Drug side effects |
| Abstract: | Cannabinoid receptor type-2 (CB2, CB2 receptor or CB2-R) mediates analgesia via two mechanisms. CB2 receptors contained in peripheral immune tissue mediate analgesia by altering cytokine profiles, and thus have little adverse effects on central nervous systems (CNSs). CB2 is also expressed in the neurons and glial cells of the CNS. This neuronal expression may also contribute to pain attenuation. The CB2 receptor has been proposed as a potential target in treating chronic pain of several etiologies. [ABSTRACT FROM PUBLISHER] |
| Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Cannabinoid receptor type-2 (CB2, CB2 receptor or CB2-R) mediates analgesia via two mechanisms. CB2 receptors contained in peripheral immune tissue mediate analgesia by altering cytokine profiles, and thus have little adverse effects on central nervous systems (CNSs). CB2 is also expressed in the neurons and glial cells of the CNS. This neuronal expression may also contribute to pain attenuation. The CB2 receptor has been proposed as a potential target in treating chronic pain of several etiologies. [ABSTRACT FROM PUBLISHER] |
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| ISSN: | 00207454 |
| DOI: | 10.1080/00207454.2016.1257992 |
