White Matter Microstructure and Information Processing at the Completion of Chemotherapy-Only Treatment for Pediatric Acute Lymphoblastic Leukemia.
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| Title: | White Matter Microstructure and Information Processing at the Completion of Chemotherapy-Only Treatment for Pediatric Acute Lymphoblastic Leukemia. |
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| Authors: | Darling, Simone J, De Luca, Cinzia, Anderson, Vicki, McCarthy, Maria, Hearps, Stephen, Seal, Marc L |
| Source: | Developmental Neuropsychology. 2018, Vol. 43 Issue 5, p385-402. 18p. 3 Black and White Photographs, 1 Diagram, 4 Charts, 2 Graphs. |
| Subjects: | Human information processing in children, Lymphoblastic leukemia treatment, Magnetic resonance imaging, Anisotropy, Cognition in children, White matter (Nerve tissue), Microstructure |
| Abstract: | Little is known about white matter microstructure and its role in information processing abilities of children treated for acute lymphoblastic leukemia (ALL) early posttreatment. Twenty-one survivors of ALL and 18 controls (7-16 years) underwent neurocognitive assessment. A subsample underwent diffusion-weighted magnetic resonance imaging. The ALL group performed poorer on measures of processing capacity, and had widespread areas of decreased fractional anisotropy and increased radial diffusivity. Significant group by white matter microstructure interactions was found when predicting processing speed. Findings provide evidence for an atypical brain-behavior relationship early posttreatment for childhood ALL. Replication in a larger sample is required. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Little is known about white matter microstructure and its role in information processing abilities of children treated for acute lymphoblastic leukemia (ALL) early posttreatment. Twenty-one survivors of ALL and 18 controls (7-16 years) underwent neurocognitive assessment. A subsample underwent diffusion-weighted magnetic resonance imaging. The ALL group performed poorer on measures of processing capacity, and had widespread areas of decreased fractional anisotropy and increased radial diffusivity. Significant group by white matter microstructure interactions was found when predicting processing speed. Findings provide evidence for an atypical brain-behavior relationship early posttreatment for childhood ALL. Replication in a larger sample is required. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 87565641 |
| DOI: | 10.1080/87565641.2018.1473401 |
