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White Matter Microstructure and Information Processing at the Completion of Chemotherapy-Only Treatment for Pediatric Acute Lymphoblastic Leukemia.

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Title: White Matter Microstructure and Information Processing at the Completion of Chemotherapy-Only Treatment for Pediatric Acute Lymphoblastic Leukemia.
Authors: Darling, Simone J, De Luca, Cinzia, Anderson, Vicki, McCarthy, Maria, Hearps, Stephen, Seal, Marc L
Source: Developmental Neuropsychology. 2018, Vol. 43 Issue 5, p385-402. 18p. 3 Black and White Photographs, 1 Diagram, 4 Charts, 2 Graphs.
Subjects: Human information processing in children, Lymphoblastic leukemia treatment, Magnetic resonance imaging, Anisotropy, Cognition in children, White matter (Nerve tissue), Microstructure
Abstract: Little is known about white matter microstructure and its role in information processing abilities of children treated for acute lymphoblastic leukemia (ALL) early posttreatment. Twenty-one survivors of ALL and 18 controls (7-16 years) underwent neurocognitive assessment. A subsample underwent diffusion-weighted magnetic resonance imaging. The ALL group performed poorer on measures of processing capacity, and had widespread areas of decreased fractional anisotropy and increased radial diffusivity. Significant group by white matter microstructure interactions was found when predicting processing speed. Findings provide evidence for an atypical brain-behavior relationship early posttreatment for childhood ALL. Replication in a larger sample is required. [ABSTRACT FROM AUTHOR]
Copyright of Developmental Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: White Matter Microstructure and Information Processing at the Completion of Chemotherapy-Only Treatment for Pediatric Acute Lymphoblastic Leukemia.
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  Data: <searchLink fieldCode="JN" term="%22Developmental+Neuropsychology%22">Developmental Neuropsychology</searchLink>. 2018, Vol. 43 Issue 5, p385-402. 18p. 3 Black and White Photographs, 1 Diagram, 4 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Human+information+processing+in+children%22">Human information processing in children</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphoblastic+leukemia+treatment%22">Lymphoblastic leukemia treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Anisotropy%22">Anisotropy</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+in+children%22">Cognition in children</searchLink><br /><searchLink fieldCode="DE" term="%22White+matter+%28Nerve+tissue%29%22">White matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22Microstructure%22">Microstructure</searchLink>
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  Data: Little is known about white matter microstructure and its role in information processing abilities of children treated for acute lymphoblastic leukemia (ALL) early posttreatment. Twenty-one survivors of ALL and 18 controls (7-16 years) underwent neurocognitive assessment. A subsample underwent diffusion-weighted magnetic resonance imaging. The ALL group performed poorer on measures of processing capacity, and had widespread areas of decreased fractional anisotropy and increased radial diffusivity. Significant group by white matter microstructure interactions was found when predicting processing speed. Findings provide evidence for an atypical brain-behavior relationship early posttreatment for childhood ALL. Replication in a larger sample is required. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Developmental Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/87565641.2018.1473401
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      – Code: eng
        Text: English
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        PageCount: 18
        StartPage: 385
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      – SubjectFull: Human information processing in children
        Type: general
      – SubjectFull: Lymphoblastic leukemia treatment
        Type: general
      – SubjectFull: Magnetic resonance imaging
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      – SubjectFull: Anisotropy
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      – SubjectFull: White matter (Nerve tissue)
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      – SubjectFull: Microstructure
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      – TitleFull: White Matter Microstructure and Information Processing at the Completion of Chemotherapy-Only Treatment for Pediatric Acute Lymphoblastic Leukemia.
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            NameFull: McCarthy, Maria
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              Text: 2018
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