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Pilot randomized controlled trial of a symptom cluster intervention in advanced cancer.

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Title:	Pilot randomized controlled trial of a symptom cluster intervention in advanced cancer.
Authors:	Wells‐Di Gregorio, Sharla M., Marks, Donald R., DeCola, Joseph, Peng, Juan, Probst, Danielle, Zaleta, Alexandra, Benson, Don, Cohn, David E., Lustberg, Maryam, Carson, William E., Magalang, Uly, Wells-Di Gregorio, Sharla M
Source:	Psycho-Oncology. Jan2019, Vol. 28 Issue 1, p76-84. 9p. 3 Charts, 1 Graph.
Subjects:	Evaluation research, Research funding, Fatigue (Physiology), Pilot projects, Insomnia, Statistical sampling, Severity of illness index, Treatment effectiveness, Randomized controlled trials, Research methodology, Research, Acceptance & commitment therapy, Tumors, Comparative studies, Mental depression, Disease complications, Psychosocial factors
Abstract:	Objective: This study evaluated a three-session acceptance-based cognitive behavioral -acceptance and commitment therapy (CBT-ACT) intervention targeting a common symptom cluster in advanced cancer-worry-insomnia-depression-fatigue.Methods: Twenty-eight patients with advanced cancer were randomly assigned to the CBT-ACT intervention or waitlist. At preintervention, participants completed a psychodiagnostic interview, standardized questionnaires, and a sleep diary. Intervention and waitlist groups were reassessed after 6 weeks, at which point the waitlist group completed the intervention.Results: Participants receiving the intervention demonstrated improved sleep efficiency (P = 0.0062, d = 1.08), sleep latency (P = 0.028, d = -0.86), insomnia severity (P = 0.0047, d = -1.18), and worry (P = 0.026, d = -0.89) compared with waitlist controls. They also demonstrated a 7-point reduction on depression (P = 0.03, d = -0.88), reduced hyperarousal (P = 0.005, d = -1.51), and a decrease in distress (P = 0.032, d = -0.83). Effects were maintained for the whole sample in sensitivity analyses. Effects on uncertainty intolerance approached significance (P = 0.058). No effect was found on fatigue.Conclusions: The CBT-ACT group performed significantly better than the waitlist control group. CBT-ACT yielded strong effects for worry, sleep, depression, emotional distress, total distress, and hyperarousal. Future studies will enhance the fatigue and uncertainty tolerance components of the intervention. [ABSTRACT FROM AUTHOR]
	Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	Psychology and Behavioral Sciences Collection
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