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EGFR Mutations in Lung Cancer: Correlation with ClinicalResponse to Gefitinib Therapy.

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Title: EGFR Mutations in Lung Cancer: Correlation with ClinicalResponse to Gefitinib Therapy.
Authors: Paez, J. Guillermo, Janne, Pasi A., Lee, Jeffrey C., Tracy, Sean, Greulich, Heidi, Gabriel, Stacey, Herman, Paula, Kaye, Frederic J., Lindeman, Neal, Boggon, Titus J., Naoki, Katsuhiko, Sasaki, Hidefumi, Fujii, Yoshitaka, Eck, Michael J., Sellers, William R., Johnson, Bruce E., Meyerson, Matthew
Source: Science (pre-March 2025). 6/4/2004, Vol. 304 Issue 5676, p1497-1500. 4p. 2 Diagrams, 1 Graph.
Subjects: Protein-tyrosine kinases, Small cell lung cancer, Genetic mutation, Tumors, Cell lines
Geographic Terms: Japan, United States
Abstract: Receptor tyrosine kinase genes were sequenced in non-small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene ECFR were found in 15 of 58 unselected tumors from Japan and 1 of 61 from the United States. Treatment with the EGFR kinase inhibitor gef itinib (Iressa) causes tumor regression in some patients with NSCLC, more frequently in Japan. ECFR mutations were found in additional lung cancer samples from D.S. patients who responded to gefitinib therapy and in a lung adenocarcinoma cell line that was hypersensitive to growth inhibition by gefitinib, but not in gefitinib-insensitive tumors or cell lines. These results suggest that ECFR mutations may predict sensitivity to gefitinib. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: EGFR Mutations in Lung Cancer: Correlation with ClinicalResponse to Gefitinib Therapy.
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  Data: <searchLink fieldCode="AR" term="%22Paez%2C+J%2E+Guillermo%22">Paez, J. Guillermo</searchLink><br /><searchLink fieldCode="AR" term="%22Janne%2C+Pasi+A%2E%22">Janne, Pasi A.</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Jeffrey+C%2E%22">Lee, Jeffrey C.</searchLink><br /><searchLink fieldCode="AR" term="%22Tracy%2C+Sean%22">Tracy, Sean</searchLink><br /><searchLink fieldCode="AR" term="%22Greulich%2C+Heidi%22">Greulich, Heidi</searchLink><br /><searchLink fieldCode="AR" term="%22Gabriel%2C+Stacey%22">Gabriel, Stacey</searchLink><br /><searchLink fieldCode="AR" term="%22Herman%2C+Paula%22">Herman, Paula</searchLink><br /><searchLink fieldCode="AR" term="%22Kaye%2C+Frederic+J%2E%22">Kaye, Frederic J.</searchLink><br /><searchLink fieldCode="AR" term="%22Lindeman%2C+Neal%22">Lindeman, Neal</searchLink><br /><searchLink fieldCode="AR" term="%22Boggon%2C+Titus+J%2E%22">Boggon, Titus J.</searchLink><br /><searchLink fieldCode="AR" term="%22Naoki%2C+Katsuhiko%22">Naoki, Katsuhiko</searchLink><br /><searchLink fieldCode="AR" term="%22Sasaki%2C+Hidefumi%22">Sasaki, Hidefumi</searchLink><br /><searchLink fieldCode="AR" term="%22Fujii%2C+Yoshitaka%22">Fujii, Yoshitaka</searchLink><br /><searchLink fieldCode="AR" term="%22Eck%2C+Michael+J%2E%22">Eck, Michael J.</searchLink><br /><searchLink fieldCode="AR" term="%22Sellers%2C+William+R%2E%22">Sellers, William R.</searchLink><br /><searchLink fieldCode="AR" term="%22Johnson%2C+Bruce+E%2E%22">Johnson, Bruce E.</searchLink><br /><searchLink fieldCode="AR" term="%22Meyerson%2C+Matthew%22">Meyerson, Matthew</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 6/4/2004, Vol. 304 Issue 5676, p1497-1500. 4p. 2 Diagrams, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Protein-tyrosine+kinases%22">Protein-tyrosine kinases</searchLink><br /><searchLink fieldCode="DE" term="%22Small+cell+lung+cancer%22">Small cell lung cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+mutation%22">Genetic mutation</searchLink><br /><searchLink fieldCode="DE" term="%22Tumors%22">Tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+lines%22">Cell lines</searchLink>
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  Label: Abstract
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  Data: Receptor tyrosine kinase genes were sequenced in non-small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene ECFR were found in 15 of 58 unselected tumors from Japan and 1 of 61 from the United States. Treatment with the EGFR kinase inhibitor gef itinib (Iressa) causes tumor regression in some patients with NSCLC, more frequently in Japan. ECFR mutations were found in additional lung cancer samples from D.S. patients who responded to gefitinib therapy and in a lung adenocarcinoma cell line that was hypersensitive to growth inhibition by gefitinib, but not in gefitinib-insensitive tumors or cell lines. These results suggest that ECFR mutations may predict sensitivity to gefitinib. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=13455821
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        Value: 10.1126/science.1099314
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        Text: English
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        PageCount: 4
        StartPage: 1497
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      – SubjectFull: Protein-tyrosine kinases
        Type: general
      – SubjectFull: Small cell lung cancer
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      – SubjectFull: Genetic mutation
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      – TitleFull: EGFR Mutations in Lung Cancer: Correlation with ClinicalResponse to Gefitinib Therapy.
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