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Gene–environment correlations in parental emotional warmth and intolerance: genome‐wide analysis over two generations of the Young Finns Study.

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Title: Gene–environment correlations in parental emotional warmth and intolerance: genome‐wide analysis over two generations of the Young Finns Study.
Authors: Dobewall, Henrik, Savelieva, Kateryna, Seppälä, Ilkka, Knafo‐Noam, Ariel, Hakulinen, Christian, Elovainio, Marko, Keltikangas‐Järvinen, Liisa, Pulkki‐Råback, Laura, Raitakari, Olli T., Lehtimäki, Terho, Hintsanen, Mirka
Source: Journal of Child Psychology & Psychiatry. Mar2019, Vol. 60 Issue 3, p277-285. 9p. 1 Diagram, 1 Chart.
Subjects: Emotions, Genetic polymorphisms, Genomes, Motherhood, Parenting, Self-evaluation, Temperament, Phenotypes
Geographic Terms: Finland
Abstract: Background: Genomic analysis of the child might offer new potential to illuminate human parenting. We examined whether offspring (G2) genome‐wide genotype variation (SNPs) is associated with their mother's (G1) emotional warmth and intolerance, indicating a gene–environment correlation. If this association is stronger than between G2′s genes and their emotional warmth and intolerance toward their own children, then this would indicate the presence of an evocative gene–environment correlation. To further understand how G1 mother's parenting has been evoked by genetically influenced characteristics of the child (G2), we examined whether child (G2) temperament partially accounted for the association between offspring genes and parental responses. Methods: Participants were from the Young Finns Study. G1 mothers (N = 2,349; mean age 39 years) self‐reported the emotional warmth and intolerance toward G2 in 1980 when the participants were from 3 to 18 years old. G2 participants answered the same parenting scales in 2007/2012 (N = 1,378; mean age = 38 years in 2007; 59% female) when their children were on average 11 years old. Offspring temperament traits were self‐reported in 1992 (G2 age range 15–30 years). Estimation of the phenotypic variance explained by the SNPs of G2 was done by genome‐wide complex trait analysis with restricted maximum likelihood (GCTA‐GREML). Results: Results showed that the SNPs of a child (G2) explained 22.6% of the phenotypic variance of maternal intolerance (G1; p‐value = .039). G2 temperament trait negative emotionality explained only 2.4% points of this association. G2 genes did not explain G1 emotional warmth or G2′s own emotional warmth and intolerance. However, further analyses of a combined measure of both G1 parenting scales found genetic effects. Parent or child gender did not moderate the observed associations. Conclusions: Presented genome‐wide evidence is pointing to the important role a child plays in affecting and shaping his/her family environment, though the underlying mechanisms remain unclear. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Gene–environment correlations in parental emotional warmth and intolerance: genome‐wide analysis over two generations of the Young Finns Study.
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  Data: <searchLink fieldCode="AR" term="%22Dobewall%2C+Henrik%22">Dobewall, Henrik</searchLink><br /><searchLink fieldCode="AR" term="%22Savelieva%2C+Kateryna%22">Savelieva, Kateryna</searchLink><br /><searchLink fieldCode="AR" term="%22Seppälä%2C+Ilkka%22">Seppälä, Ilkka</searchLink><br /><searchLink fieldCode="AR" term="%22Knafo‐Noam%2C+Ariel%22">Knafo‐Noam, Ariel</searchLink><br /><searchLink fieldCode="AR" term="%22Hakulinen%2C+Christian%22">Hakulinen, Christian</searchLink><br /><searchLink fieldCode="AR" term="%22Elovainio%2C+Marko%22">Elovainio, Marko</searchLink><br /><searchLink fieldCode="AR" term="%22Keltikangas‐Järvinen%2C+Liisa%22">Keltikangas‐Järvinen, Liisa</searchLink><br /><searchLink fieldCode="AR" term="%22Pulkki‐Råback%2C+Laura%22">Pulkki‐Råback, Laura</searchLink><br /><searchLink fieldCode="AR" term="%22Raitakari%2C+Olli+T%2E%22">Raitakari, Olli T.</searchLink><br /><searchLink fieldCode="AR" term="%22Lehtimäki%2C+Terho%22">Lehtimäki, Terho</searchLink><br /><searchLink fieldCode="AR" term="%22Hintsanen%2C+Mirka%22">Hintsanen, Mirka</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Child+Psychology+%26+Psychiatry%22">Journal of Child Psychology & Psychiatry</searchLink>. Mar2019, Vol. 60 Issue 3, p277-285. 9p. 1 Diagram, 1 Chart.
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  Data: <searchLink fieldCode="DE" term="%22Emotions%22">Emotions</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Genomes%22">Genomes</searchLink><br /><searchLink fieldCode="DE" term="%22Motherhood%22">Motherhood</searchLink><br /><searchLink fieldCode="DE" term="%22Parenting%22">Parenting</searchLink><br /><searchLink fieldCode="DE" term="%22Self-evaluation%22">Self-evaluation</searchLink><br /><searchLink fieldCode="DE" term="%22Temperament%22">Temperament</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Finland%22">Finland</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background: Genomic analysis of the child might offer new potential to illuminate human parenting. We examined whether offspring (G2) genome‐wide genotype variation (SNPs) is associated with their mother's (G1) emotional warmth and intolerance, indicating a gene–environment correlation. If this association is stronger than between G2′s genes and their emotional warmth and intolerance toward their own children, then this would indicate the presence of an evocative gene–environment correlation. To further understand how G1 mother's parenting has been evoked by genetically influenced characteristics of the child (G2), we examined whether child (G2) temperament partially accounted for the association between offspring genes and parental responses. Methods: Participants were from the Young Finns Study. G1 mothers (N = 2,349; mean age 39 years) self‐reported the emotional warmth and intolerance toward G2 in 1980 when the participants were from 3 to 18 years old. G2 participants answered the same parenting scales in 2007/2012 (N = 1,378; mean age = 38 years in 2007; 59% female) when their children were on average 11 years old. Offspring temperament traits were self‐reported in 1992 (G2 age range 15–30 years). Estimation of the phenotypic variance explained by the SNPs of G2 was done by genome‐wide complex trait analysis with restricted maximum likelihood (GCTA‐GREML). Results: Results showed that the SNPs of a child (G2) explained 22.6% of the phenotypic variance of maternal intolerance (G1; p‐value = .039). G2 temperament trait negative emotionality explained only 2.4% points of this association. G2 genes did not explain G1 emotional warmth or G2′s own emotional warmth and intolerance. However, further analyses of a combined measure of both G1 parenting scales found genetic effects. Parent or child gender did not moderate the observed associations. Conclusions: Presented genome‐wide evidence is pointing to the important role a child plays in affecting and shaping his/her family environment, though the underlying mechanisms remain unclear. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/jcpp.12995
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 277
    Subjects:
      – SubjectFull: Emotions
        Type: general
      – SubjectFull: Genetic polymorphisms
        Type: general
      – SubjectFull: Genomes
        Type: general
      – SubjectFull: Motherhood
        Type: general
      – SubjectFull: Parenting
        Type: general
      – SubjectFull: Self-evaluation
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      – SubjectFull: Temperament
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      – SubjectFull: Finland
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      – TitleFull: Gene–environment correlations in parental emotional warmth and intolerance: genome‐wide analysis over two generations of the Young Finns Study.
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              Text: Mar2019
              Type: published
              Y: 2019
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