Postnatal Refinement of Peripheral Olfactory Projections.
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| Title: | Postnatal Refinement of Peripheral Olfactory Projections. |
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| Authors: | Zou, Dong-Jing, Feinstein, Paul, Rivers, Aimée L., Mathews, Glennis A., Kim, Ann, Greer, Charles A., Mombaerts, Peter, Firestein, Stuart |
| Source: | Science (pre-March 2025). 6/25/2004, Vol. 304 Issue 5679, p1976-1979. 4p. 1 Diagram, 1 Chart, 4 Graphs, 1 Map. |
| Subjects: | Axons, Smell, Sensory neurons, Kidney glomerulus, Genes, Mice |
| Abstract: | Axonal projections from the olfactory epithelium to the olfactory bulb are organized into glomeruli according to the expressed odorant receptor. Using gene-targeted mice, we show that glomerular maturation proceeds along different time courses for two similar receptors and requires sensory input during distinct sensitive periods. During early development, some glomeruli are innervated by axons of neurons that do not express the same receptor. These heterogeneous glomeruli normally disappear with age, but they persist in adults deprived of sensory input by unilateral and permanent naris closure. Persistence may be due, in part, to prolonged survival of olfactory sensory neurons. [ABSTRACT FROM AUTHOR] |
| Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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