The role of clock genes in perinatal depression: the light in the darkness.
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| Title: | The role of clock genes in perinatal depression: the light in the darkness. |
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| Authors: | Buoli, M. (AUTHOR), Grassi, S. (AUTHOR), Iodice, S. (AUTHOR), Carnevali, G. S. (AUTHOR), Esposito, C. M. (AUTHOR), Tarantini, L. (AUTHOR), Barkin, J. L. (AUTHOR), Bollati, V. (AUTHOR) |
| Source: | Acta Psychiatrica Scandinavica. Oct2019, Vol. 140 Issue 4, p382-384. 3p. 1 Chart. |
| Subjects: | Clock genes, Chronobiology disorders, Prenatal depression, Prenatal bonding, Edinburgh Postnatal Depression Scale |
| Abstract: | Circadian rhythms are altered in major depressive disorder (MDD) as showed by changes in circadian patterns of gene expression in the human brain of subjects affected by MDD [1]. Similarly, one study suggests that clock gene expression in tissues related to pregnancy is altered in mice during pregnancy, although this has not been tested yet in humans [3]. I CLOCK i hyper-methylation and I CRY1, PER1, and PER2 i hypo-methylation are suggestive of a delay in circadian rhythms that is typical of pregnant women with a history of MDD as showed by shifts in dim light melatonin onset [[9]]. We hypothesize that depression in pregnancy causes a further delay of circadian rhythms (already present in physiological pregnancy) [11]. [Extracted from the article] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Circadian rhythms are altered in major depressive disorder (MDD) as showed by changes in circadian patterns of gene expression in the human brain of subjects affected by MDD [1]. Similarly, one study suggests that clock gene expression in tissues related to pregnancy is altered in mice during pregnancy, although this has not been tested yet in humans [3]. I CLOCK i hyper-methylation and I CRY1, PER1, and PER2 i hypo-methylation are suggestive of a delay in circadian rhythms that is typical of pregnant women with a history of MDD as showed by shifts in dim light melatonin onset [[9]]. We hypothesize that depression in pregnancy causes a further delay of circadian rhythms (already present in physiological pregnancy) [11]. [Extracted from the article] |
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| ISSN: | 0001690X |
| DOI: | 10.1111/acps.13084 |
