Adaptive archaic introgression of copy number variants and the discovery of previously unknown human genes.
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| Title: | Adaptive archaic introgression of copy number variants and the discovery of previously unknown human genes. |
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| Authors: | Hsieh, PingHsun, Vollger, Mitchell R., Dang, Vy, Porubsky, David, Baker, Carl, Cantsilieris, Stuart, Hoekzema, Kendra, Lewis, Alexandra P., Munson, Katherine M., Sorensen, Melanie, Kronenberg, Zev N., Murali, Shwetha, Nelson, Bradley J., Chiatante, Giorgia, Maggiolini, Flavia Angela Maria, Blanché, Hélène, Underwood, Jason G., Antonacci, Francesca, Deleuze, Jean-François, Eichler, Evan E. |
| Source: | Science (pre-March 2025). 10/18/2019, Vol. 366 Issue 6463, p324-324. 1p. 1 Diagram. |
| Subjects: | DNA copy number variations, Nucleotide sequencing, Inferential statistics, Hominids, Population |
| Abstract: | The article presents a study that focuses on the discovery of introgressed and adaptive copy number variants (CNVs) that have become enriched in specific human populations. The study combine whole-genome CNV calling and population genetic inference methods to discover CNVs and then assess signals of selection after controlling for demographic history. The study found a significant excess of CNV sharing between modern non-African populations and archaic hominins. |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | The article presents a study that focuses on the discovery of introgressed and adaptive copy number variants (CNVs) that have become enriched in specific human populations. The study combine whole-genome CNV calling and population genetic inference methods to discover CNVs and then assess signals of selection after controlling for demographic history. The study found a significant excess of CNV sharing between modern non-African populations and archaic hominins. |
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| ISSN: | 00368075 |
| DOI: | 10.1126/science.aax2083 |
