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Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation.

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Title: Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation.
Authors: Burger, Andreas Michael (AUTHOR), D'Agostini, Martina (AUTHOR), Verkuil, Bart (AUTHOR), Van Diest, Ilse (AUTHOR)
Source: Psychophysiology. Jun2020, Vol. 57 Issue 6, p1-24. 24p. 1 Diagram, 7 Charts.
Subjects: Treatment effectiveness, Biomarkers, Somatosensory evoked potentials, Heart beat, Vagus nerve stimulation
Abstract: Transcutaneous vagus nerve stimulation (tVNS) is a non‐invasive neurostimulation technique that is currently being tested as a potential treatment for a myriad of neurological and psychiatric disorders. However, the working mechanisms underlying tVNS are poorly understood and it remains unclear whether stimulation activates the vagus nerve for every participant. Finding a biological marker of tVNS is imperative, as it can help guide research on clinical applications and can inform researchers on optimal stimulation sites and parameters to further optimize treatment efficacy. In this narrative review, we discuss five potential biomarkers for tVNS and review currently available evidence for these markers for both invasive and tVNS. While some of these biomarkers hold promise from a theoretical perspective, none of the potential biomarkers provide clear and definitive indications that tVNS increases the vagal activity or augments activity in the locus coeruleus‐noradrenaline network. We conclude the review by providing several recommendations for how to tackle the challenges and opportunities when researching potential biomarkers for the effects of tVNS. This narrative review offers a comprehensive overview of research findings related to the potential biomarkers of transcutaneous vagus nerve stimulation (tVNS). None of the biomarkers provide clear indications that tVNS increases vagal activation or affects central areas believed to mediate its effects. The mixed findings in tVNS research may reflect suboptimal experimental assessment standards. Recommendations for future research on potential biomarkers are provided. [ABSTRACT FROM AUTHOR]
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Database: Psychology and Behavioral Sciences Collection
Description
Abstract:Transcutaneous vagus nerve stimulation (tVNS) is a non‐invasive neurostimulation technique that is currently being tested as a potential treatment for a myriad of neurological and psychiatric disorders. However, the working mechanisms underlying tVNS are poorly understood and it remains unclear whether stimulation activates the vagus nerve for every participant. Finding a biological marker of tVNS is imperative, as it can help guide research on clinical applications and can inform researchers on optimal stimulation sites and parameters to further optimize treatment efficacy. In this narrative review, we discuss five potential biomarkers for tVNS and review currently available evidence for these markers for both invasive and tVNS. While some of these biomarkers hold promise from a theoretical perspective, none of the potential biomarkers provide clear and definitive indications that tVNS increases the vagal activity or augments activity in the locus coeruleus‐noradrenaline network. We conclude the review by providing several recommendations for how to tackle the challenges and opportunities when researching potential biomarkers for the effects of tVNS. This narrative review offers a comprehensive overview of research findings related to the potential biomarkers of transcutaneous vagus nerve stimulation (tVNS). None of the biomarkers provide clear indications that tVNS increases vagal activation or affects central areas believed to mediate its effects. The mixed findings in tVNS research may reflect suboptimal experimental assessment standards. Recommendations for future research on potential biomarkers are provided. [ABSTRACT FROM AUTHOR]
ISSN:00485772
DOI:10.1111/psyp.13571