Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation.
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| Title: | Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation. |
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| Authors: | Burger, Andreas Michael (AUTHOR), D'Agostini, Martina (AUTHOR), Verkuil, Bart (AUTHOR), Van Diest, Ilse (AUTHOR) |
| Source: | Psychophysiology. Jun2020, Vol. 57 Issue 6, p1-24. 24p. 1 Diagram, 7 Charts. |
| Subjects: | Treatment effectiveness, Biomarkers, Somatosensory evoked potentials, Heart beat, Vagus nerve stimulation |
| Abstract: | Transcutaneous vagus nerve stimulation (tVNS) is a non‐invasive neurostimulation technique that is currently being tested as a potential treatment for a myriad of neurological and psychiatric disorders. However, the working mechanisms underlying tVNS are poorly understood and it remains unclear whether stimulation activates the vagus nerve for every participant. Finding a biological marker of tVNS is imperative, as it can help guide research on clinical applications and can inform researchers on optimal stimulation sites and parameters to further optimize treatment efficacy. In this narrative review, we discuss five potential biomarkers for tVNS and review currently available evidence for these markers for both invasive and tVNS. While some of these biomarkers hold promise from a theoretical perspective, none of the potential biomarkers provide clear and definitive indications that tVNS increases the vagal activity or augments activity in the locus coeruleus‐noradrenaline network. We conclude the review by providing several recommendations for how to tackle the challenges and opportunities when researching potential biomarkers for the effects of tVNS. This narrative review offers a comprehensive overview of research findings related to the potential biomarkers of transcutaneous vagus nerve stimulation (tVNS). None of the biomarkers provide clear indications that tVNS increases vagal activation or affects central areas believed to mediate its effects. The mixed findings in tVNS research may reflect suboptimal experimental assessment standards. Recommendations for future research on potential biomarkers are provided. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 143150028 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Burger%2C+Andreas+Michael%22">Burger, Andreas Michael</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22D'Agostini%2C+Martina%22">D'Agostini, Martina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Verkuil%2C+Bart%22">Verkuil, Bart</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Van+Diest%2C+Ilse%22">Van Diest, Ilse</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychophysiology%22">Psychophysiology</searchLink>. Jun2020, Vol. 57 Issue 6, p1-24. 24p. 1 Diagram, 7 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Somatosensory+evoked+potentials%22">Somatosensory evoked potentials</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+beat%22">Heart beat</searchLink><br /><searchLink fieldCode="DE" term="%22Vagus+nerve+stimulation%22">Vagus nerve stimulation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Transcutaneous vagus nerve stimulation (tVNS) is a non‐invasive neurostimulation technique that is currently being tested as a potential treatment for a myriad of neurological and psychiatric disorders. However, the working mechanisms underlying tVNS are poorly understood and it remains unclear whether stimulation activates the vagus nerve for every participant. Finding a biological marker of tVNS is imperative, as it can help guide research on clinical applications and can inform researchers on optimal stimulation sites and parameters to further optimize treatment efficacy. In this narrative review, we discuss five potential biomarkers for tVNS and review currently available evidence for these markers for both invasive and tVNS. While some of these biomarkers hold promise from a theoretical perspective, none of the potential biomarkers provide clear and definitive indications that tVNS increases the vagal activity or augments activity in the locus coeruleus‐noradrenaline network. We conclude the review by providing several recommendations for how to tackle the challenges and opportunities when researching potential biomarkers for the effects of tVNS. This narrative review offers a comprehensive overview of research findings related to the potential biomarkers of transcutaneous vagus nerve stimulation (tVNS). None of the biomarkers provide clear indications that tVNS increases vagal activation or affects central areas believed to mediate its effects. The mixed findings in tVNS research may reflect suboptimal experimental assessment standards. Recommendations for future research on potential biomarkers are provided. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=143150028 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/psyp.13571 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 24 StartPage: 1 Subjects: – SubjectFull: Treatment effectiveness Type: general – SubjectFull: Biomarkers Type: general – SubjectFull: Somatosensory evoked potentials Type: general – SubjectFull: Heart beat Type: general – SubjectFull: Vagus nerve stimulation Type: general Titles: – TitleFull: Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Burger, Andreas Michael – PersonEntity: Name: NameFull: D'Agostini, Martina – PersonEntity: Name: NameFull: Verkuil, Bart – PersonEntity: Name: NameFull: Van Diest, Ilse IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 00485772 Numbering: – Type: volume Value: 57 – Type: issue Value: 6 Titles: – TitleFull: Psychophysiology Type: main |
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