Examining the Relationship between a Verbal Incidental Learning Measure from the WAIS-IV and Neuroimaging Biomarkers for Alzheimer's Pathology.
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| Title: | Examining the Relationship between a Verbal Incidental Learning Measure from the WAIS-IV and Neuroimaging Biomarkers for Alzheimer's Pathology. |
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| Authors: | Hammers, Dustin B. (AUTHOR), Kucera, Amanda (AUTHOR), Spencer, Robert J. (AUTHOR), Abildskov, Tracy J. (AUTHOR), Archibald, Zane G. (AUTHOR), Hoffman, John M. (AUTHOR), Wilde, Elizabeth A. (AUTHOR) |
| Source: | Developmental Neuropsychology. Apr-Jun2020, Vol. 45 Issue 3, p95-109. 15p. 4 Charts, 2 Graphs. |
| Subjects: | Incidental learning, Verbal learning, Neuropsychological tests, Wechsler Adult Intelligence Scale, Pathology, Brain imaging, Biomarkers |
| Abstract: | Convergent validation of a verbal incidental learning (IL) task from the WAIS-IV using neuroimaging biomarkers is warranted to understand its sensitivity to Alzheimer's disease (AD) pathology. Fifty-five memory clinic patients aged 59 to 87 years received neuropsychological assessment, and measures of IL and quantitative brain imaging. Worse IL-Total Score and IL-Similarities performances were significantly associated with smaller hemispheric hippocampal volumes. IL measures were not significantly correlated with cerebral β-amyloid burden, though a trend was present and effect sizes were mild. These hippocampal volume results suggest that this IL task may be sensitive to AD pathology along the AD continuum. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Convergent validation of a verbal incidental learning (IL) task from the WAIS-IV using neuroimaging biomarkers is warranted to understand its sensitivity to Alzheimer's disease (AD) pathology. Fifty-five memory clinic patients aged 59 to 87 years received neuropsychological assessment, and measures of IL and quantitative brain imaging. Worse IL-Total Score and IL-Similarities performances were significantly associated with smaller hemispheric hippocampal volumes. IL measures were not significantly correlated with cerebral β-amyloid burden, though a trend was present and effect sizes were mild. These hippocampal volume results suggest that this IL task may be sensitive to AD pathology along the AD continuum. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 87565641 |
| DOI: | 10.1080/87565641.2020.1762602 |
