Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.
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| Title: | Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. |
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| Authors: | Roark, Ryan S., Li, Hui, Williams, Wilton B., Chug, Hema, Mason, Rosemarie D., Gorman, Jason, Wang, Shuyi, Lee, Fang-Hua, Rando, Juliette, Bonsignori, Mattia, Hwang, Kwan-Ki, Saunders, Kevin O., Wiehe, Kevin, Moody, M. Anthony, Hraber, Peter T., Wagh, Kshitij, Giorgi, Elena E., Russell, Ronnie M., Bibollet-Ruche, Frederic, Liu, Weimin |
| Source: | Science (pre-March 2025). 1/8/2021, Vol. 371 Issue 6525, p142-142. 1p. 1 Color Photograph. |
| Subjects: | HIV antibodies, Macaques, AIDS vaccines, Vaccine development, Phosphates, B cells, Biomechanics |
| Abstract: | The article presents a research on recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. Topics include development of an effective neutralizing antibody–based HIV-1 vaccine will require consistent activation of multiple germline precursor B cells; and enabling the molecular, biological, and immunological mechanisms responsible for responses to be studied in a reproducible and iterative fashion. |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | The article presents a research on recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. Topics include development of an effective neutralizing antibody–based HIV-1 vaccine will require consistent activation of multiple germline precursor B cells; and enabling the molecular, biological, and immunological mechanisms responsible for responses to be studied in a reproducible and iterative fashion. |
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| ISSN: | 00368075 |
| DOI: | 10.1126/science.abd2638 |
