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Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.

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Title: Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.
Authors: Roark, Ryan S., Li, Hui, Williams, Wilton B., Chug, Hema, Mason, Rosemarie D., Gorman, Jason, Wang, Shuyi, Lee, Fang-Hua, Rando, Juliette, Bonsignori, Mattia, Hwang, Kwan-Ki, Saunders, Kevin O., Wiehe, Kevin, Moody, M. Anthony, Hraber, Peter T., Wagh, Kshitij, Giorgi, Elena E., Russell, Ronnie M., Bibollet-Ruche, Frederic, Liu, Weimin
Source: Science (pre-March 2025). 1/8/2021, Vol. 371 Issue 6525, p142-142. 1p. 1 Color Photograph.
Subjects: HIV antibodies, Macaques, AIDS vaccines, Vaccine development, Phosphates, B cells, Biomechanics
Abstract: The article presents a research on recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. Topics include development of an effective neutralizing antibody–based HIV-1 vaccine will require consistent activation of multiple germline precursor B cells; and enabling the molecular, biological, and immunological mechanisms responsible for responses to be studied in a reproducible and iterative fashion.
Database: Psychology and Behavioral Sciences Collection
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Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 148028027
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
  Group: Ti
  Data: Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Roark%2C+Ryan+S%2E%22">Roark, Ryan S.</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Hui%22">Li, Hui</searchLink><br /><searchLink fieldCode="AR" term="%22Williams%2C+Wilton+B%2E%22">Williams, Wilton B.</searchLink><br /><searchLink fieldCode="AR" term="%22Chug%2C+Hema%22">Chug, Hema</searchLink><br /><searchLink fieldCode="AR" term="%22Mason%2C+Rosemarie+D%2E%22">Mason, Rosemarie D.</searchLink><br /><searchLink fieldCode="AR" term="%22Gorman%2C+Jason%22">Gorman, Jason</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Shuyi%22">Wang, Shuyi</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Fang-Hua%22">Lee, Fang-Hua</searchLink><br /><searchLink fieldCode="AR" term="%22Rando%2C+Juliette%22">Rando, Juliette</searchLink><br /><searchLink fieldCode="AR" term="%22Bonsignori%2C+Mattia%22">Bonsignori, Mattia</searchLink><br /><searchLink fieldCode="AR" term="%22Hwang%2C+Kwan-Ki%22">Hwang, Kwan-Ki</searchLink><br /><searchLink fieldCode="AR" term="%22Saunders%2C+Kevin+O%2E%22">Saunders, Kevin O.</searchLink><br /><searchLink fieldCode="AR" term="%22Wiehe%2C+Kevin%22">Wiehe, Kevin</searchLink><br /><searchLink fieldCode="AR" term="%22Moody%2C+M%2E+Anthony%22">Moody, M. Anthony</searchLink><br /><searchLink fieldCode="AR" term="%22Hraber%2C+Peter+T%2E%22">Hraber, Peter T.</searchLink><br /><searchLink fieldCode="AR" term="%22Wagh%2C+Kshitij%22">Wagh, Kshitij</searchLink><br /><searchLink fieldCode="AR" term="%22Giorgi%2C+Elena+E%2E%22">Giorgi, Elena E.</searchLink><br /><searchLink fieldCode="AR" term="%22Russell%2C+Ronnie+M%2E%22">Russell, Ronnie M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bibollet-Ruche%2C+Frederic%22">Bibollet-Ruche, Frederic</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Weimin%22">Liu, Weimin</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 1/8/2021, Vol. 371 Issue 6525, p142-142. 1p. 1 Color Photograph.
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  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22HIV+antibodies%22">HIV antibodies</searchLink><br /><searchLink fieldCode="DE" term="%22Macaques%22">Macaques</searchLink><br /><searchLink fieldCode="DE" term="%22AIDS+vaccines%22">AIDS vaccines</searchLink><br /><searchLink fieldCode="DE" term="%22Vaccine+development%22">Vaccine development</searchLink><br /><searchLink fieldCode="DE" term="%22Phosphates%22">Phosphates</searchLink><br /><searchLink fieldCode="DE" term="%22B+cells%22">B cells</searchLink><br /><searchLink fieldCode="DE" term="%22Biomechanics%22">Biomechanics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article presents a research on recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. Topics include development of an effective neutralizing antibody–based HIV-1 vaccine will require consistent activation of multiple germline precursor B cells; and enabling the molecular, biological, and immunological mechanisms responsible for responses to be studied in a reproducible and iterative fashion.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=148028027
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      – Type: doi
        Value: 10.1126/science.abd2638
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: 142
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      – SubjectFull: HIV antibodies
        Type: general
      – SubjectFull: Macaques
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      – SubjectFull: AIDS vaccines
        Type: general
      – SubjectFull: Vaccine development
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      – SubjectFull: Phosphates
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      – SubjectFull: B cells
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      – SubjectFull: Biomechanics
        Type: general
    Titles:
      – TitleFull: Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.
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              M: 01
              Text: 1/8/2021
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              Y: 2021
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