Bibliographic Details
| Title: |
Functional implications of CaMKII alternative splicing. |
| Authors: |
Sloutsky, Roman (AUTHOR), Stratton, Margaret M. (AUTHOR) |
| Source: |
European Journal of Neuroscience. Oct2021, Vol. 54 Issue 8, p6780-6794. 15p. 4 Diagrams, 1 Chart. |
| Subjects: |
Alternative RNA splicing, Long-term potentiation, Protein kinases, Calmodulin, Synapses, Human genes |
| Abstract: |
Ca2+/calmodulin‐dependent protein kinase II (CaMKII) is known to be a crucial regulator in the post‐synapse during long‐term potentiation. This important protein has been the subject of many studies centered on understanding memory at the molecular, cellular, and organismic level. CaMKII is encoded by four genes in humans, all of which undergo alternative splicing at the RNA level, leading to an enormous diversity of expressed proteins. Advances in sequencing technologies have facilitated the discovery of many new CaMKII transcripts. To date, newly discovered CaMKII transcripts have been incorporated into an ambiguous naming scheme. Herein, we review the initial experiments leading to the discovery of CaMKII and its subsequent variants. We propose the adoption of a new, unambiguous naming scheme for CaMKII variants. Finally, we discuss biological implications for CaMKII splice variants. [ABSTRACT FROM AUTHOR] |
|
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Psychology and Behavioral Sciences Collection |
